{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T18:35:47Z","timestamp":1789583747092,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,7,29]],"date-time":"2013-07-29T00:00:00Z","timestamp":1375056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"CAPES (Coordena\u00e7\u00e3o de aperfei\u00e7oamento de Pessoal de N\u00edvel Superior)"},{"name":"CNPq (Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico)","award":["482635\/2010-0"],"award-info":[{"award-number":["482635\/2010-0"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Chromoblastomycosis is a chronic mycosis that affects the skin and subcutaneous tissues caused by several genera of dematiaceous fungi. There is not a treatment of choice. Thus, tools that help guide clinical practice are fundamental. In this sense, antifungal activity tests <jats:italic>in vitro<\/jats:italic> could be useful. However, trials with chromoblastomycosis agents are scarce. The aim of this study was to evaluate both the <jats:italic>in vitro<\/jats:italic> susceptibility of 60 chromoblastomycosis agents to five antifungals and the combination of amphotericin B (AMB) and terbinafine (<jats:styled-content style=\"fixed-case\">TRB<\/jats:styled-content>). <jats:styled-content style=\"fixed-case\">TRB<\/jats:styled-content>, itraconazole (ITZ) and ketoconazole (<jats:styled-content style=\"fixed-case\">KTZ<\/jats:styled-content>) were, in this order, the drugs which showed better activity against the chromoblastomycosis agents. The less active drugs were voriconazole (<jats:styled-content style=\"fixed-case\">VRZ<\/jats:styled-content>) and AMB. The more differentiated group was <jats:italic><jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>xophiala spinifera<\/jats:italic>. <jats:italic><jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ladophialophora carrionii<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>onsecaea<\/jats:italic> spp. are significantly more susceptible to <jats:styled-content style=\"fixed-case\">KTZ<\/jats:styled-content> than <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>hialophora verrucosa<\/jats:italic>, whereas <jats:italic><jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>.\u00a0carrionii<\/jats:italic> is significantly more sensitive to <jats:styled-content style=\"fixed-case\">VRZ<\/jats:styled-content> than <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>.\u00a0verrucosa<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>.\u00a0spinifera<\/jats:italic>. Assays in this direction allow the knowledge of the susceptibility of the causative agents which may help the management of patients with this disease. This study includes the largest number of these agents and of genera found in the literature.<\/jats:p>","DOI":"10.1111\/myc.12111","type":"journal-article","created":{"date-parts":[[2013,7,30]],"date-time":"2013-07-30T03:56:27Z","timestamp":1375156587000},"page":"116-120","source":"Crossref","is-referenced-by-count":34,"title":["<i>In vitro<\/i> susceptibility of chromoblastomycosis agents to five antifungal drugs and to the combination of terbinafine and amphotericin B"],"prefix":"10.1111","volume":"57","author":[{"given":"Tatiane C.","family":"Daboit","sequence":"first","affiliation":[{"name":"Postgraduate Program in Medicine: Medical Sciences Universidade Federal do Rio Grande do Sul Porto Alegre Brazil"},{"name":"Department of Microbiology, Immunology and Parasitology ICBS Universidade Federal do Rio Grande do Sul Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cibele","family":"Massotti 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