{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T21:16:51Z","timestamp":1790975811824,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,8,19]],"date-time":"2013-08-19T00:00:00Z","timestamp":1376870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>In superficial tinea and pityriasis versicolor, the causative fungi are for the most part confined to the stratum corneum which is barely reached by leukocytes. Therefore, a role of non\u2010cellular components in the epidermal antifungal defence was suggested. To investigate the presence of such factors in these infections, the expression of human beta defensins 2 and 3 (<jats:styled-content style=\"fixed-case\">hBD<\/jats:styled-content>\u20102, <jats:styled-content style=\"fixed-case\">hBD<\/jats:styled-content>\u20103), RNase 7, psoriasin, toll\u2010like receptors 2, 4 and 9 (TLR2, TLR4 and TLR9) and dectin 2 was analysed by use of immunostainings in skin biopsies. We found that <jats:styled-content style=\"fixed-case\">hBD<\/jats:styled-content>2, <jats:styled-content style=\"fixed-case\">hBD<\/jats:styled-content>3, psoriasin, RNase7, TLR2 and TLR4 were significantly more often expressed in distinct layers of lesional epidermis as compared with uninfected epidermis. In both infections but not in normal skin, <jats:styled-content style=\"fixed-case\">hBD<\/jats:styled-content>2 and <jats:styled-content style=\"fixed-case\">hBD<\/jats:styled-content>3 were commonly expressed within the stratum corneum and in the stratum granulosum. Similarly, psoriasin was seen more often in the upper skin layers of both infections as compared with normal skin. No significant differences between normal and infected skin were found for the expression of <jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>9 and dectin 2. Our findings clearly show the expression of specific antimicrobial proteins and defence\u2010related ligands in superficial tinea as well as in pityriasis versicolor, suggesting that these factors contribute to fungal containment.<\/jats:p>","DOI":"10.1111\/myc.12118","type":"journal-article","created":{"date-parts":[[2013,8,19]],"date-time":"2013-08-19T06:52:46Z","timestamp":1376895166000},"page":"147-152","source":"Crossref","is-referenced-by-count":51,"title":["Expression of antimicrobial peptides and toll\u2010like receptors is increased in tinea and pityriasis versicolor"],"prefix":"10.1111","volume":"57","author":[{"given":"J.","family":"Brasch","sequence":"first","affiliation":[{"name":"Department of Dermatology University Hospitals of Schleswig\u2010Holstein Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"M\u00f6rig","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospitals of Schleswig\u2010Holstein Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Neumann","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospitals of Schleswig\u2010Holstein Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Proksch","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospitals of Schleswig\u2010Holstein Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,8,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3302472"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2005.23935.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/648408"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2007.02782.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R300028200"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxr046"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.268"},{"key":"e_1_2_6_9_1","first-page":"65","article-title":"A simple sequentially rejective multiple test procedure","volume":"6","author":"Holm S","year":"1979","journal-title":"Scand J Statistics"},{"key":"e_1_2_6_10_1","doi-asserted-by":"crossref","first-page":"178","DOI":"10.5858\/2003-127-178-IIRRIN","article-title":"Innate immune\u2010related receptors in normal and psoriatic skin","volume":"127","author":"Curry JL","year":"2003","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_6_11_1","unstructured":"KiemerAK.Angeborenes Immunsystem. TLR er\u00f6ffnen neue M\u00f6glichkeiten. Pharmazeutische Zeitung.http:\/\/www.pharmazeutische-zeitung.de\/index.php?id=4546(online 04\/2008)."},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.161293498"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0365-05962011000400015"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000128582"},{"key":"e_1_2_6_15_1","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1038\/sj.jid.5700788","article-title":"Barrier function, epidermal differentiation, and human beta\u2010 defensin 2 expression in tinea corporis","volume":"127","author":"Proksch E","year":"2007","journal-title":"J Invest Dermatol"},{"key":"e_1_2_6_16_1","article-title":"Psoriasin: key molecule of the cutaneous barrier?","author":"Gl\u00e4ser R","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-2725(99)00013-8"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-005-5364-0"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.3109\/13693786.2012.660203"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fmyc.12118","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.12118","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T18:10:37Z","timestamp":1696270237000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/myc.12118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,19]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1111\/myc.12118"],"URL":"https:\/\/doi.org\/10.1111\/myc.12118","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,19]]}}}