{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:15:45Z","timestamp":1792696545843,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,3,12]],"date-time":"2014-03-12T00:00:00Z","timestamp":1394582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Luliconazole is a novel, broad\u2010spectrum, imidazole antifungal under development in the <jats:styled-content style=\"fixed-case\">USA<\/jats:styled-content> as a treatment for dermatophytic skin and nail infections. <jats:italic>In vitro<\/jats:italic>, luliconazole is one of the most potent antifungal agents against filamentous fungi including dermatophytes. Luliconazole has been formulated in a 10% solution with unique molecular properties, which allow it to penetrate the nail plate and rapidly achieve fungicidal levels in the nail unit. These properties make luliconazole a potent compound in the treatment of onychomycosis. This article reviews the development of luliconazole solution, 10% its molecular properties, preclinical and clinical data and its future perspectives for the treatment of fungal infections.<\/jats:p>","DOI":"10.1111\/myc.12168","type":"journal-article","created":{"date-parts":[[2014,3,13]],"date-time":"2014-03-13T02:57:14Z","timestamp":1394679434000},"page":"389-393","source":"Crossref","is-referenced-by-count":65,"title":["Luliconazole: a review of a new antifungal agent for the topical treatment of onychomycosis"],"prefix":"10.1111","volume":"57","author":[{"given":"Richard K.","family":"Scher","sequence":"first","affiliation":[{"name":"Weill Cornell Medical College Cornell Medical School New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norifumi","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Topica Pharmaceuticals, Inc. Los Altos CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Tavakkol","sequence":"additional","affiliation":[{"name":"Topica Pharmaceuticals, Inc. Los Altos CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,3,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.2003.tb02797.x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-280X.1999.00243.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05255-11"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10156-006-0440-4"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2006.01218.x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2006.01305.x"},{"key":"e_1_2_11_8_1","first-page":"1","article-title":"Onychomycosis \u2014 an overview","author":"Dahdah MK","year":"2006","journal-title":"US Dermatol Rev"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2710.2009.01107.x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1997.00163.x"},{"key":"e_1_2_11_11_1","first-page":"111","article-title":"Onychomycosis in diabetic patients: to treat or not to treat","volume":"3","author":"Pollak RA","year":"2005","journal-title":"Podiatry Management"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.11.3.415"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.107754"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.16.2.157"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.12788\/j.sder.0014"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yadr.2006.07.001"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/03639045.2011.637931"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02370-12"},{"key":"e_1_2_11_19_1","article-title":"Onychomycosis update","author":"Lipner S","year":"2014","journal-title":"Cutis"},{"key":"e_1_2_11_20_1","unstructured":"KogaH TogaT NanjohY TsuboiR YamaguchiH.The durable effect of luliconazole in a guinea pig tinea pedis model. Poster presented at the International Society for Human and Animal Mycology (ISHAM) Congress; May 25\u201329 Tokyo Japan 2009."},{"key":"e_1_2_11_21_1","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1128\/AAC.42.4.967","article-title":"In vitro and in vivo antidermatophyte activities of NND\u2010502, a novel optically active imidazole antimycotic agent","volume":"42","author":"Niwano Y","year":"1998","journal-title":"Antimicrob Agents Chemother"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-8579(99)00076-X"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10156-004-0327-1"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-8579(02)00362-X"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/13693780802541518"},{"key":"e_1_2_11_26_1","unstructured":"BrownM TurnerR NakamuraN.Nail permeation and depth profiling of luliconazole a novel imidazole antifungal agent for the topical treatment of onychomycosis. Poster presented at the 53rd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC); September 10\u201313 Denver CO USA 2013."},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.1.216-223.2004"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2012.681779"},{"key":"e_1_2_11_29_1","first-page":"203","article-title":"Luliconazole for the treatment of the interdigital tinea pedis: a double\u2010blind, vehicle\u2010controlled study","volume":"91","author":"Jarratt M","year":"2013","journal-title":"Cutis"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.105284"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.3109\/13693780903373811"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1997.tb06127.x"},{"key":"e_1_2_11_33_1","unstructured":"M Brown R Turner N Nakamura 2013"},{"key":"e_1_2_11_34_1","unstructured":"T Jones A Tavakkol 2012"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fmyc.12168","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.12168","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T23:54:53Z","timestamp":1696204493000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/myc.12168"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,12]]},"references-count":33,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["10.1111\/myc.12168"],"URL":"https:\/\/doi.org\/10.1111\/myc.12168","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,12]]}}}