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The objective of this study was to evaluate the risk factors associated with the clinical outcomes of <jats:styled-content style=\"fixed-case\">DH<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">AIDS<\/jats:styled-content> coinfection in patients from the state of Cear\u00e1, Brazil. A retrospective cohort of <jats:styled-content style=\"fixed-case\">AIDS<\/jats:styled-content> patients, after their hospital discharge due to first <jats:styled-content style=\"fixed-case\">DH<\/jats:styled-content> episode in the period 2002\u20132008, was followed until December 31, 2010, to investigate the factors associated with relapse and mortality. A total of 145 patients were evaluated in the study. Thirty patients (23.3%) relapsed and the overall mortality was 30.2%. The following variables were significantly (<jats:italic>P<\/jats:italic> &lt; 0.05) associated with relapse and overall mortality (univariate analysis): non\u2010adherence to highly active antiretroviral therapy (<jats:styled-content style=\"fixed-case\">HAART<\/jats:styled-content>), irregular use of an antifungal, non\u2010recovery of the <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4+ count and having <jats:styled-content style=\"fixed-case\">AIDS<\/jats:styled-content> before <jats:styled-content style=\"fixed-case\">DH<\/jats:styled-content>; histoplasmosis relapse was also significantly associated with mortality. In the multivariate analysis, non\u2010adherence to <jats:styled-content style=\"fixed-case\">HAART<\/jats:styled-content> was the independent risk factor that was associated with both relapse (Adj <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a06.28) and overall mortality (Adj <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a08.03); efavirenz usage was discovered to be significant only for the overall mortality rate (Adj <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a04.50). Adherence to <jats:styled-content style=\"fixed-case\">HAART<\/jats:styled-content> was the most important variable that influenced the outcomes in this specific population.<\/jats:p>","DOI":"10.1111\/myc.12175","type":"journal-article","created":{"date-parts":[[2014,2,24]],"date-time":"2014-02-24T18:25:41Z","timestamp":1393266341000},"page":"406-413","source":"Crossref","is-referenced-by-count":23,"title":["Disseminated histoplasmosis in <scp>HIV<\/scp>\u2010infected patients: determinants of relapse and mortality in a north\u2010eastern area of Brazil"],"prefix":"10.1111","volume":"57","author":[{"given":"Lisandra Serra","family":"Damasceno","sequence":"first","affiliation":[{"name":"Department of Community Health School of Medicine Federal University of Cear\u00e1 Fortaleza CE Brazil"},{"name":"Hospital S\u00e3o Jos\u00e9 of Infectious Disease Fortaleza CE Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Alberto Novaes","family":"Ramos","sequence":"additional","affiliation":[{"name":"Department of Community Health School of Medicine Federal University of Cear\u00e1 Fortaleza CE Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Henrique","family":"Alencar","sequence":"additional","affiliation":[{"name":"Department of Community Health School of Medicine Federal University of Cear\u00e1 Fortaleza CE Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria V\u00e2nia Freitas","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Hospital S\u00e3o Jos\u00e9 of Infectious Disease Fortaleza CE Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jac\u00f3 Ricarte Lima","family":"de Mesquita","sequence":"additional","affiliation":[{"name":"Hospital S\u00e3o Jos\u00e9 of Infectious Disease Fortaleza CE Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Taumaturgo Dias","family":"Soares","sequence":"additional","affiliation":[{"name":"Department of Community Health School of Medicine Federal University of Cear\u00e1 Fortaleza CE Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Gisele Nunes","family":"Coutinho","sequence":"additional","affiliation":[{"name":"Department of Community Health School of Medicine Federal University of Cear\u00e1 Fortaleza CE Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina Cavalcante","family":"Dantas","sequence":"additional","affiliation":[{"name":"Department of Community Health School of Medicine Federal University of Cear\u00e1 Fortaleza CE Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terezinha do Menino Jesus Silva","family":"Leit\u00e3o","sequence":"additional","affiliation":[{"name":"Department of Community Health School of Medicine Federal University of Cear\u00e1 Fortaleza CE Brazil"},{"name":"Hospital S\u00e3o Jos\u00e9 of Infectious Disease Fortaleza CE Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,2,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2009.02.002"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5520(02)00039-9"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/428842"},{"key":"e_1_2_7_5_1","first-page":"1","article-title":"Guidelines for prevention and treatment of opportunistic infections in HIV\u2010infected adults and adolescents: recommendations from CDC, the National Institutes of Health, and the HIV Medicine Association of the Infectious Diseases Society of America","volume":"58","author":"Centers for Disease Control and Prevention","year":"2009","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1086\/500405"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.qco.0000244049.15888.b9"},{"key":"e_1_2_7_8_1","doi-asserted-by":"crossref","first-page":"600","DOI":"10.4269\/ajtmh.2006.74.600","article-title":"Risk factors for death in acquired immunodeficiency syndrome\u2010associated disseminated histoplasmosis","volume":"74","author":"Franchesco Daher E","year":"2006","journal-title":"Am J Trop Med Hyg"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0037-86822010000100007"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2012.05.003"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02762009000300019"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1086\/313752"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1086\/521259"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1086\/420749"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12067"},{"key":"e_1_2_7_16_1","unstructured":"Programa Nacional de DST e AIDS. 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