{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T19:14:36Z","timestamp":1757704476794},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,3,18]],"date-time":"2014-03-18T00:00:00Z","timestamp":1395100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The saturated potassium iodide solution (SSKI) as treatment for sporotrichosis may cause hypothyroidism by suppressing the synthesis of thyroid hormones (<jats:styled-content style=\"fixed-case\">tT<\/jats:styled-content><jats:sub>3<\/jats:sub> and <jats:styled-content style=\"fixed-case\">tT<\/jats:styled-content><jats:sub>4<\/jats:sub>) and the iodine excess could lead to thyrotoxicosis. Evaluating the changes in serum levels of TSH, <jats:styled-content style=\"fixed-case\">tT<\/jats:styled-content>3 and <jats:styled-content style=\"fixed-case\">tT<\/jats:styled-content>4 in euthyroid patients with sporotrichosis treated with SSKI. For the selection of euthyroid patients, TSH, <jats:styled-content style=\"fixed-case\">tT<\/jats:styled-content><jats:sub>3<\/jats:sub> and <jats:styled-content style=\"fixed-case\">tT<\/jats:styled-content><jats:sub>4<\/jats:sub> concentrations were measured for those adults and children diagnosed with sporotrichosis. Each paediatric patient was administered SSKI orally in increasing doses of 2\u201320 drops\/3 times\/day and 4\u201340 drops\/3 times\/day in adults. Serum concentrations of TSH, <jats:styled-content style=\"fixed-case\">tT<\/jats:styled-content><jats:sub>3<\/jats:sub> and <jats:styled-content style=\"fixed-case\">tT<\/jats:styled-content><jats:sub>4<\/jats:sub> were measured 20\u00a0days after started the treatment and 15\u00a0days posttreatment. Eight euthyroid patients aged between 2 to 65\u00a0years old were included. After 20\u00a0days of treatment, two suffered subclinical hypothyroidism, one developed subclinical hyperthyroidism, and one hyperthyroxinaemia euthyroid. At 15\u00a0days posttreatment only four patients were evaluated and all serum levels of TSH, <jats:styled-content style=\"fixed-case\">tT<\/jats:styled-content><jats:sub>3<\/jats:sub> and <jats:styled-content style=\"fixed-case\">tT<\/jats:styled-content><jats:sub>4<\/jats:sub> were normal. Some euthyroid patients with sporotrichosis can develop hyperthyroidism or subclinical iodine\u2010induced hypothyroidism, during the administration of 3 or 6\u00a0g SSKI\/day.<\/jats:p>","DOI":"10.1111\/myc.12182","type":"journal-article","created":{"date-parts":[[2014,3,18]],"date-time":"2014-03-18T05:16:45Z","timestamp":1395119805000},"page":"460-465","source":"Crossref","is-referenced-by-count":5,"title":["Effects of potassium iodide in concentrations of TSH, <scp>tT<\/scp><sub>3<\/sub> and <scp>tT<\/scp><sub>4<\/sub> in serum of subjects with sporotrichosis"],"prefix":"10.1111","volume":"57","author":[{"given":"Max Carlos","family":"Ram\u00edrez Soto","sequence":"first","affiliation":[{"name":"Pathology Department Regional Hospital Guillermo Diaz de la Vega of Apurimac Peru"},{"name":"Clinical Pathology Service Santa Teresa Clinic Abancay Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,3,18]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"149","volume-title":"Micolog\u00eda M\u00e9dica Ilustrada","author":"Arenas R","year":"2008"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00808-07"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199604000-00014"},{"key":"e_1_2_7_5_1","first-page":"121","article-title":"Clinical and epidemiological profile of sporotrichosis in a reference clinic at Abancay, Peru: 2004\u20132011","volume":"16","author":"Ram\u00edrez\u2010Soto M","year":"2012","journal-title":"Rev peru epidemiol"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1086\/522765"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00437024"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/105072501300176462"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-45-5-504"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa054022"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1497.1997.07109.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2010.0417"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-011-8997-x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.76.4.928"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1997.2721081.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/105072501300176453"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.140.8.3404"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.1998.8.83"},{"volume-title":"Dietary reference intakes","year":"2006","author":"Institute of Medicine","key":"e_1_2_7_19_1"},{"key":"e_1_2_7_20_1","first-page":"1492","volume-title":"Meyler's side effects of drugs","author":"Weeke J","year":"2000"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2000.10.141"},{"key":"e_1_2_7_22_1","first-page":"98","article-title":"Effect of potassium iodide on the immune response in the sporotrichosis","volume":"14","author":"Torres B","year":"1997","journal-title":"Rev Iberoam Micol"},{"key":"e_1_2_7_23_1","first-page":"18","article-title":"Sporotrichosis in childhood. 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