{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:06:03Z","timestamp":1790661963186,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,3,18]],"date-time":"2014-03-18T00:00:00Z","timestamp":1395100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Clinical <jats:italic>Paracoccidioides<\/jats:italic> spp. isolates from patients with paracoccidioidomycosis (<jats:styled-content style=\"fixed-case\">PCM<\/jats:styled-content>) in Mato Grosso, Brazil exhibit different patterns of serologic reactivity. The results observed for reactions of radial immunodiffusion against the commonly used exoantigens containing a 43\u2010kDa glycoprotein (gp43) suggest that this fungus exhibits major antigenic variability by geographic region. There is a phylogenetic gap between <jats:italic>Paracoccidioides<\/jats:italic> spp. isolates among different regions of Latin America. In particular, those from the central region of Brazil (i.e. Mato Grosso state) exhibit a lower rate of genetic similarity. We aimed at investigating the phylogenetic classification of clinical isolates of <jats:italic>Paracoccidioides<\/jats:italic> spp. in Central Brazil and the different antigenic profiles that produce. Exoantigens were obtained from five clinical isolates: two <jats:italic>P.\u00a0brasiliensis<\/jats:italic> (Pb166 and Pb2880) and three <jats:italic>P.\u00a0lutzii<\/jats:italic> (PL2875, PL9840, and PL2912). The protein\/glycoprotein profiles of <jats:italic>P.\u00a0lutzii<\/jats:italic> exoantigens were different from each other. Isolate PL9840 exhibited the most distinct bands, and isolates PL2875 and PL2912 exhibited more diffuse bands and a very intense band between 50 and 60\u00a0kDa. <jats:italic>P.\u00a0brasiliensis<\/jats:italic> isolates had similar protein profiles, exhibiting a low\u2010intensity band at 220\u00a0kDa and a diffuse band between 50 and 60\u00a0kDa. <jats:italic>P.\u00a0lutzii<\/jats:italic> isolates exhibit high species\u2010specific antigen variability, which we have already been assessed in proteomic studies.<\/jats:p>","DOI":"10.1111\/myc.12183","type":"journal-article","created":{"date-parts":[[2014,3,18]],"date-time":"2014-03-18T09:14:59Z","timestamp":1395134099000},"page":"466-472","source":"Crossref","is-referenced-by-count":37,"title":["Serological and antigenic profiles of clinical isolates of <i>Paracoccidioides<\/i> spp. from Central Western Brazil"],"prefix":"10.1111","volume":"57","author":[{"given":"Luiz de P\u00e1dua","family":"Queiroz J\u00fanior","sequence":"first","affiliation":[{"name":"Mycology\/Research Laboratory Faculty of Medicine Federal University of Mato Grosso UFMT Cuiab\u00e1 Mato Grosso Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoilo Pires","family":"de Camargo","sequence":"additional","affiliation":[{"name":"Mycology Laboratory Federal University of S\u00e3o Paulo UNIFESP S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Tadano","sequence":"additional","affiliation":[{"name":"J\u00falio Muller University Hospital UFMT Cuiab\u00e1 Mato Grosso Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anderson Messias","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Mycology Laboratory Federal University of S\u00e3o Paulo UNIFESP S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doracilde Terumi","family":"Takarara","sequence":"additional","affiliation":[{"name":"MT Laboratory State Department of Health Cuiab\u00e1 Mato Grosso Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Gegembauer","sequence":"additional","affiliation":[{"name":"Mycology Laboratory Federal University of S\u00e3o Paulo UNIFESP S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia Mendes","family":"Araujo","sequence":"additional","affiliation":[{"name":"Mycology Laboratory Federal University of S\u00e3o Paulo UNIFESP S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosane Christine","family":"Hahn","sequence":"additional","affiliation":[{"name":"Mycology\/Research Laboratory Faculty of Medicine Federal University of Mato Grosso UFMT Cuiab\u00e1 Mato Grosso Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,3,18]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"125","article-title":"Estudos comparativos do granuloma coccidi\u00f3ico nos Estados Unidos e no Brasil. Novo g\u00eanero para o parasito brasileiro","volume":"5","author":"Almeida FP","year":"1930","journal-title":"An Fac Med Sao Paulo"},{"key":"e_1_2_5_3_1","first-page":"19","article-title":"Paracoccidioides lutzii sp. Nov.: biological and clinical implications","volume":"52","author":"Teixeira MM","year":"2014","journal-title":"Med Mycol"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0036-46652002000500013"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0037-86821987000200012"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/00362178585380481"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/02681218780000231"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.6.2.89"},{"key":"e_1_2_5_9_1","first-page":"28","volume-title":"Prevalence of Systemic Mycoses in Latin America","author":"Borelli D","year":"1970"},{"key":"e_1_2_5_10_1","first-page":"428","article-title":"La epidemiolog\u00eda de la paracoccidioidomicosis","volume":"83","author":"Greer DL","year":"1977","journal-title":"Bol Of Sanit Panam"},{"key":"e_1_2_5_11_1","volume-title":"Paracoccidioidomicose: Blastomicose sul\u2010americana","author":"Del Negro G","year":"1982"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0037-86822006000300017"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-311X2002000500037"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2013.07.019"},{"key":"e_1_2_5_15_1","first-page":"41","article-title":"Current knowledge on pathogenesis and immunodiagnosis of paracoccidioidomycosis","volume":"17","author":"Camargo ZP","year":"2000","journal-title":"Rev Iberoam Micol"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(02)00078-3"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0034-89101992000100003"},{"key":"e_1_2_5_18_1","first-page":"902","article-title":"Experimental paracoccidioidomycosis in alcoholic rats","volume":"24","author":"Goldani LZ","year":"1991","journal-title":"Braz J Med Biol"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.2000.0824"},{"key":"e_1_2_5_20_1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/jlb.57.1.101","article-title":"Comparative ultrastructure and immunolabeling of MHC\u2010II antigens of alveolar macrophages obtained from patients with paracoccidioidomycosis and other lung diseases","volume":"57","author":"Breta\u00f1a A","year":"1995","journal-title":"J Leukoc Biol"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00430-009-0138-1"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.36.6.1733-1736.1998"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.7.2849-2854.2003"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ympev.2009.04.005"},{"key":"e_1_2_5_25_1","unstructured":"BatistaJJr.Exoant\u00edgenos obtidos de isolados cl\u00ednicos de Paracoccidioides brasiliensis procedentes do estado de Mato Grosso e sua import\u00e2ncia regional no imunodiagn\u00f3stico da paracoccidioidomicose.Cuiab\u00e1. Disserta\u00e7\u00e3o [Mestrado em Ci\u00eancias da Sa\u00fade: Doen\u00e7as Infecciosas e Parasit\u00e1rias]:Universidade Federal de Mato Grosso 2006."},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2008.01687.x"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/13693780310001615358"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0037694"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyp207"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2007.00901.x"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.1150080203"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.8.4553"},{"key":"e_1_2_5_33_1","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1128\/iai.53.1.199-206.1986","article-title":"Exocellular components of Paracoccidioides brasiliensis: identification of a specific antigen","volume":"53","author":"Puccia R","year":"1986","journal-title":"Infect Immun"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-007-9055-2"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2003.07.008"},{"key":"e_1_2_5_36_1","unstructured":"GrossklausDA.An\u00e1lise da express\u00e3o de genes relacionados \u00e0 virul\u00eancia e caracteriza\u00e7\u00e3o imunoqu\u00edmica de exoant\u00edgenos obtidos de isolados cl\u00ednicos de Paracoccidioides brasiliensis de Mato Grosso acometidos por distintas formas cl\u00ednicas da paracoccidioidomicose.Cuiab\u00e1. Disserta\u00e7\u00e3o [Mestrado em Ci\u00eancias da Sa\u00fade: Doen\u00e7as Infecciosas e Tropicais e Micologia M\u00e9dica]:Universidade Federal de mato Grosso 2008."},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2012.12-0340"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00439292"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.9.4350"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fmyc.12183","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.12183","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T01:56:02Z","timestamp":1696470962000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/myc.12183"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,18]]},"references-count":39,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1111\/myc.12183"],"URL":"https:\/\/doi.org\/10.1111\/myc.12183","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,18]]}}}