{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:13:52Z","timestamp":1790727232084,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,3,28]],"date-time":"2014-03-28T00:00:00Z","timestamp":1395964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2014,8]]},"abstract":"Summary<\/jats:title>\n \n Aspergillus<\/jats:italic>\n tracheobronchitis (\n ATB<\/jats:styled-content>\n ) is considered as an unusual form of invasive aspergillosis and has a fatal outcome. There is little current information on several aspects of chronic obstructive pulmonary diseases (\n COPD<\/jats:styled-content>\n ) complicated by\n ATB<\/jats:styled-content>\n , the frequency of which is expected to increase in the coming years. In a prospective study of invasive bronchial\u2010pulmonary aspergillosis (\n IBPA<\/jats:styled-content>\n ) in a critically ill\n COPD<\/jats:styled-content>\n population, three proven cases of\n ATB<\/jats:styled-content>\n were identified. The three new cases, combined with eight previously reported cases of\n COPD<\/jats:styled-content>\n with\n ATB<\/jats:styled-content>\n over a 30\u2010year period (1983\u20132013), were analysed. Among 153 critically ill\n COPD<\/jats:styled-content>\n patients admitted to the\n ICU<\/jats:styled-content>\n , eight cases were complicated by\n ATB<\/jats:styled-content>\n [23.5% of\n IBPA<\/jats:styled-content>\n (8 of 34); and 5.2% of\n COPD<\/jats:styled-content>\n (8 of 153)], and three cases were finally diagnosed as proven\n ATB<\/jats:styled-content>\n by histopathological findings. Among the three new cases reported and the eight published cases, the overall mortality rate was 72.7% (8 of 11 cases), with a median of 11.5\u00a0days (range, 7\u201327\u00a0days) between admission to death. The mortality rate was significantly higher in patients with invasive pulmonary aspergillosis (\n IPA<\/jats:styled-content>\n ) [100% (8 of 8 patients)] than in patients without parenchyma invasion [0% (0 of 3 patient),\n P<\/jats:italic>\n \u00a0=\u00a00.006]. Seven patients (77.8%) received systemic corticosteroid therapy and three patients (33.3%) inhaled corticosteroids before diagnosis with\n ATB<\/jats:styled-content>\n . Dyspnoea resistant to corticosteroids (77.8%) was the most frequent symptom. The radiological manifestations progressed rapidly in three patients (75%) who had normal chest X\u2010rays (\n CXR<\/jats:styled-content>\n s) at admission. Pseudomembranous lesions were the most frequent form (54.5%) observed by bronchoscopy.\n Aspergillus fumigatus<\/jats:italic>\n was the most frequently isolated pathogen (40%).\n ATB<\/jats:styled-content>\n is an uncommon cause of exacerbation in approximately 5% of critically ill\n COPD<\/jats:styled-content>\n patients admitted to the\n ICU<\/jats:styled-content>\n , and may progress rapidly to\n IPA<\/jats:styled-content>\n with a high mortality rate. Dyspnoea resistant to corticosteroids and appropriate antibiotics with a negative\n CXR<\/jats:styled-content>\n should raise the suspicion of\n ATB<\/jats:styled-content>\n . Early diagnosis of\n ATB<\/jats:styled-content>\n is based on bronchoscopic examination and proven diagnosis maybe safely established with a bronchial mucous biopsy.\n <\/jats:p>","DOI":"10.1111\/myc.12185","type":"journal-article","created":{"date-parts":[[2014,3,28]],"date-time":"2014-03-28T17:13:27Z","timestamp":1396026807000},"page":"473-482","source":"Crossref","is-referenced-by-count":19,"title":["Aspergillus<\/i>\n tracheobronchitis in critically ill patients with chronic obstructive pulmonary diseases"],"prefix":"10.1111","volume":"57","author":[{"given":"Hangyong","family":"He","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Beijing Chao\u2010Yang Hospital Capital Medical University Beijing China"},{"name":"Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders Beijing Institute of Respiratory Medicine Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Beijing Chao\u2010Yang Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Beijing Chao\u2010Yang Hospital Capital Medical University Beijing China"},{"name":"Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders Beijing Institute of Respiratory Medicine Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Beijing Chao\u2010Yang Hospital Capital Medical University Beijing China"},{"name":"Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders Beijing Institute of Respiratory Medicine Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Li","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders Beijing Institute of Respiratory Medicine Beijing China"},{"name":"Department of Infectious Diseases and Clinical Microbiology Beijing Chao\u2010Yang Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyuan","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Beijing Chao\u2010Yang Hospital Capital Medical University Beijing China"},{"name":"Department of Critical Care Medicine China\u2010Japan Friendship Hospital Ministry of Health Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders Beijing Institute of Respiratory Medicine Beijing China"},{"name":"Institute of Respiratory Medicine Beijing Hospital Ministry of Health Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,3,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/588660"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00062206"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200401-093OC"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2005.01143.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2009.03015.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc9402"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11908-010-0132-1"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e31826c2ccf"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001340000768"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc11443"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/13693786.2010.521523"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.50.7.812"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1086\/517672"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1086\/518852"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2006.03.006"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1086\/341971"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199201000-00028"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200008243430818"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.46.1.15"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200703-456SO"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc10138"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2005.01180.x"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.38.6.478"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-199107000-00004"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.101.3.870"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/106002809502901209"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.50.7.807"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2004.022046"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/SMJ.0b013e3181d39008"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fmyc.12185","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.12185","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T21:56:04Z","timestamp":1696456564000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/myc.12185"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,28]]},"references-count":29,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1111\/myc.12185"],"URL":"https:\/\/doi.org\/10.1111\/myc.12185","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,28]]}}}