{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T14:24:45Z","timestamp":1759847085727},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,4,3]],"date-time":"2014-04-03T00:00:00Z","timestamp":1396483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Hyperkeratotic\u2010type tinea pedis is chronic and recalcitrant to topical antifungal agents. Some topical antifungal agents are effective; however, long duration of therapy is required, which often reduce the treatment compliance of patients. To seek for short period therapy of hyperkeratotic type tinea pedis, in this study, we observed the efficacy and safety of treatment of topical terbinafine and 10% urea ointment combined oral terbinafine. Participants with hyperkeratotic type tinea pedis were randomly assigned to two groups. Patients in group I were treated with oral terbinafine for 2\u00a0weeks and topical terbinafine and 10% urea ointment for 4\u00a0weeks, whereas in group <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>, only the above topical agents were applied for 12\u00a0weeks. Clinical improvement rates and fungal eradication rates were compared between the two groups at 24\u00a0weeks after the initiation of treatment. The group I had stopped the topical therapy 8\u00a0weeks earlier than group <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>. There were no significant differences in mycological eradication rates and clinical improvement rates between the two groups, besides, no major side effects were noted in both groups. The short combination therapy with oral terbinafine was effective and safe; it should be a valuable option for patients with hyperkeratotic type tinea pedis.<\/jats:p>","DOI":"10.1111\/myc.12198","type":"journal-article","created":{"date-parts":[[2014,4,4]],"date-time":"2014-04-04T02:43:09Z","timestamp":1396579389000},"page":"560-564","source":"Crossref","is-referenced-by-count":3,"title":["Combination treatment of oral terbinafine with topical terbinafine and 10% urea ointment in hyperkeratotic type tinea pedis"],"prefix":"10.1111","volume":"57","author":[{"given":"Tian\u2010Wei","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Dermatology the First Affiliated Hospital of Zhengzhou University Zhengzhou China"},{"name":"Department of Dermatology People's Hospital of Zhengzhou Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiang\u2010An","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology the First Affiliated Hospital of Zhengzhou University Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xian\u2010Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Surgery Zhengzhou Children's Hospital Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong\u2010Xing","family":"Yu","sequence":"additional","affiliation":[{"name":"Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong\u2010Bo","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Zhongshan School of Medicine Sun Yat\u2010Sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian\u2010Bin","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Dermatology the First Affiliated Hospital of Zhengzhou University Zhengzhou 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