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The objective of this study was to evaluate the occurrence and antifungal resistance of 1694 isolates of non\u2010<jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CSP<\/jats:styled-content> collected during the period 2006\u20132011. Isolates were recovered in 33 hospitals located in four regions: Northcentral, North\u2010east, South\u2010east and West and tested using <jats:styled-content style=\"fixed-case\">CLSI<\/jats:styled-content> reference broth microdilution methods. Non\u2010<jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CSP<\/jats:styled-content> represented 55.6% of all <jats:italic>Candida<\/jats:italic>. <jats:italic>C. glabrata<\/jats:italic> was most predominant (39\u201342% of non\u2010<jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CSP<\/jats:styled-content>). Infections due to <jats:italic>C. glabrata, C. krusei<\/jats:italic> and <jats:italic>C. dubliniensis<\/jats:italic> increased over the 6 years. Anidulafungin (3.6%) and caspofungin (5.7%) resistance were prominent among <jats:italic>C. glabrata<\/jats:italic> from the North\u2010east and West regions respectively. Resistance to micafungin was detected in 2.0% and 2.9% of <jats:italic>C. glabrata<\/jats:italic> from the West and North\u2010east regions respectively. Echinocandin resistance was low, except for <jats:italic>C. dubliniensis<\/jats:italic>. Azole resistance was most prominent among <jats:italic>C. glabrata<\/jats:italic> from the South\u2010east (13.6% fluconazole R) and the West (18.0%). Cross\u2010resistance among three tested azoles was observed in <jats:italic>C. glabrata<\/jats:italic> from all regions. Whereas differences in species distribution and antifungal R varied across geographic regions, there was little evidence of temporal increase in resistance to azoles or echinocandins in the monitored non\u2010<jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CSP<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/myc.12206","type":"journal-article","created":{"date-parts":[[2014,5,26]],"date-time":"2014-05-26T09:38:58Z","timestamp":1401097138000},"page":"602-611","source":"Crossref","is-referenced-by-count":86,"title":["Regional data analysis of <i>Candida<\/i> non\u2010<i>albicans<\/i> strains collected in United States medical sites over a 6\u2010year period, 2006\u20132011"],"prefix":"10.1111","volume":"57","author":[{"given":"Michael A.","family":"Pfaller","sequence":"first","affiliation":[{"name":"JMI Laboratories North Liberty IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald N.","family":"Jones","sequence":"additional","affiliation":[{"name":"JMI Laboratories North Liberty IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Castanheira","sequence":"additional","affiliation":[{"name":"JMI Laboratories North Liberty IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,5,26]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3004404"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0195-6701(95)90036-5"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/10408410903241444"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit136"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12212"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit140"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2011.11.001"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2012.06.012"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp080325"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1754"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis697"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1411.080337"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1086\/591033"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2012.02.001"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/9781555817176.ch29"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2012.10.003"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00946-09"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2010.01.002"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.06112-11"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2007.10.014"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1086\/596757"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24507"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/phar.1186"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm260"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23465"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02117-09"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00308-13"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1128\/9781555816728.ch115"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01686-12"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-012-9551-x"},{"key":"e_1_2_5_32_1","volume-title":"M27\u2010A3. 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