{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T05:38:54Z","timestamp":1791005934933,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,6,25]],"date-time":"2014-06-25T00:00:00Z","timestamp":1403654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The cut\u2010off values of immunological tests employed in diagnosis of allergic bronchopulmonary aspergillosis (ABPA) have never been validated. Herein, we compare the immunological findings in patients with ABPA and asthma using receiver operating characteristic analysis. Consecutive asthmatic subjects underwent all the following investigations: <jats:italic>Aspergillus<\/jats:italic> skin test, IgE levels (total and <jats:italic>A<\/jats:italic>.\u00a0<jats:italic>fumigatus\u2010<\/jats:italic>specific), <jats:italic>Aspergillus<\/jats:italic> precipitins, eosinophil count, chest radiograph and CT chest. There were 372 subjects (179 men, mean age 35.9\u00a0years) with a mean asthma duration of 8\u00a0years. ABPA was diagnosed in 76 patients (64 bronchiectasis, 12 without bronchiectasis). ABPA was separated from asthma using the best cut\u2010off values of total IgE, <jats:italic>A.\u00a0fumigatus<\/jats:italic> IgE and total eosinophil count of\u00a02347\u00a0IU\u00a0ml<jats:sup>\u22121<\/jats:sup>, 1.91\u00a0kUA\u00a0l<jats:sup>\u22121<\/jats:sup> and 507 cells per \u03bcl respectively. The sensitivity\/specificity of these parameters were 87\/81%; 99\/87%; and, 79\/76% respectively. The corresponding AUC values were 0.95, 0.90 and 0.82 respectively. The combination of these three tests at the aforementioned cut\u2010offs provided 100% specificity. Our study provides evidence\u2010based cut\u2010off values of IgE (total and <jats:italic>A.\u00a0fumigatus\u2010<\/jats:italic>specific) and eosinophil counts in differentiating ABPA from asthma. As this is a single centre retrospective study, further studies from different centres are required, as these values could vary by ethnicity and environmental exposure.<\/jats:p>","DOI":"10.1111\/myc.12214","type":"journal-article","created":{"date-parts":[[2014,6,25]],"date-time":"2014-06-25T08:35:25Z","timestamp":1403685325000},"page":"659-663","source":"Crossref","is-referenced-by-count":73,"title":["Cut\u2010off values of serum IgE (total and <i>A.\u00a0fumigatus<\/i> \u2010specific) and eosinophil count in differentiating allergic bronchopulmonary aspergillosis from asthma"],"prefix":"10.1111","volume":"57","author":[{"given":"Ritesh","family":"Agarwal","sequence":"first","affiliation":[{"name":"Department of Pulmonary Medicine Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashutosh N.","family":"Aggarwal","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandeep","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biman","family":"Saikia","sequence":"additional","affiliation":[{"name":"Department of Immunopathology Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arunaloke","family":"Chakrabarti","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,25]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-2586"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1295716"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.13.116"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2012.03.001"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-86-4-405"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12141"},{"key":"e_1_2_5_8_1","first-page":"6","article-title":"Controversies in allergic bronchopulmonary aspergillosis","volume":"6","author":"Agarwal R","year":"2010","journal-title":"Int J Respir Care"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1986.00360170130020"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-96-3-286"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061105"},{"key":"e_1_2_5_12_1","first-page":"567","article-title":"Development of a simple computer program for spirometry interpretation","volume":"50","author":"Aggarwal AN","year":"2002","journal-title":"J Assoc Physicians India"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197102252840805"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.2307\/2531595"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(1950)3:1<32::AID-CNCR2820030106>3.0.CO;2-3"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.130.2.442"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-011-0217-4"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/13693786.2010.504752"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.04.007"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fmyc.12214","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.12214","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T08:47:37Z","timestamp":1696236457000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/myc.12214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,25]]},"references-count":18,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["10.1111\/myc.12214"],"URL":"https:\/\/doi.org\/10.1111\/myc.12214","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,25]]}}}