{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T22:52:24Z","timestamp":1789080744672,"version":"build-2803163510"},"reference-count":51,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,7,15]],"date-time":"2014-07-15T00:00:00Z","timestamp":1405382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The purpose of this study was to evaluate a preemptive approach with serum 1,3\u2010beta\u2010<jats:sc>d<\/jats:sc>\u2010glucan (<jats:styled-content style=\"fixed-case\">BDG<\/jats:styled-content>) as a marker for treatment stratification of systemic antifungal (<jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>) therapy in patients with clinical suspected invasive fungal infections (<jats:styled-content style=\"fixed-case\">IFI<\/jats:styled-content>) at intensive care units (<jats:styled-content style=\"fixed-case\">ICU<\/jats:styled-content>), and the impact of surgical procedures. A total of 66 <jats:styled-content style=\"fixed-case\">ICU<\/jats:styled-content> patients with clinical suspected <jats:styled-content style=\"fixed-case\">IFI<\/jats:styled-content> were included in this retrospective analysis. Serum <jats:styled-content style=\"fixed-case\">BDG<\/jats:styled-content> testing was performed prior to initiation of <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content> treatment and in addition to routine diagnostic measures. Based on the <jats:styled-content style=\"fixed-case\">BDG<\/jats:styled-content> results the initial clinical decision whether or not to start systemic <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content> therapy was re\u2010evaluated. Impact of surgical procedures on clinical utility of serum <jats:styled-content style=\"fixed-case\">BDG<\/jats:styled-content> was evaluated in a sub\u2010group of 25 patients who had undergone surgical procedures prior to <jats:styled-content style=\"fixed-case\">BDG<\/jats:styled-content> evaluation. <jats:styled-content style=\"fixed-case\">BDG<\/jats:styled-content> test results led to discontinuation of <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content> therapy in 13 patients, and initiation of <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content> therapy in seven patients. In 46 patients the clinical decision was confirmed by <jats:styled-content style=\"fixed-case\">BDG<\/jats:styled-content>. The majority of suspected, probable and proven <jats:styled-content style=\"fixed-case\">IFI<\/jats:styled-content> cases (10\/13, 77%) was predicted by the test. <jats:styled-content style=\"fixed-case\">BDG<\/jats:styled-content> testing turned out positive in 9\/25 (36%) of patients that had undergone recent surgery and levels correlated with clinical findings. Serum <jats:styled-content style=\"fixed-case\">BDG<\/jats:styled-content> evaluation seems to be a promising tool to guide <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content> therapy in <jats:styled-content style=\"fixed-case\">ICU<\/jats:styled-content> patients even after recent surgical procedures.<\/jats:p>","DOI":"10.1111\/myc.12221","type":"journal-article","created":{"date-parts":[[2014,7,16]],"date-time":"2014-07-16T03:53:55Z","timestamp":1405482835000},"page":"679-686","source":"Crossref","is-referenced-by-count":37,"title":["Serum 1,3\u2010beta\u2010<scp>d<\/scp>\u2010glucan for antifungal treatment stratification at the intensive care unit and the influence of surgery"],"prefix":"10.1111","volume":"57","author":[{"given":"J\u00fcrgen","family":"Prattes","sequence":"first","affiliation":[{"name":"Section of Infectious Diseases and Tropical Medicine Medical University of Graz Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Hoenigl","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases and Tropical Medicine Medical University of Graz Graz Austria"},{"name":"Division of Pulmonology Medical University of Graz Graz Austria"},{"name":"Division of Infectious Diseases University of California San Diego San Diego CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmin","family":"Rabensteiner","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases and Tropical Medicine Medical University of Graz Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhard B.","family":"Raggam","sequence":"additional","affiliation":[{"name":"Clinical Institute of Medical and Chemical Laboratory Diagnostics Medical University of Graz Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Prueller","sequence":"additional","affiliation":[{"name":"Clinical Institute of Medical and Chemical Laboratory Diagnostics Medical University of Graz Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ines","family":"Zollner\u2010Schwetz","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases and Tropical Medicine Medical University of Graz Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Valentin","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases and Tropical Medicine Medical University of Graz Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"H\u00f6nigl","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases and Tropical Medicine Medical University of Graz Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Fruhwald","sequence":"additional","affiliation":[{"name":"Division of Anesthesiology for Cardiovascular Surgery and Intensive Care Medicine Department of Anesthesiology and Intensive Care Medicine Medical University of Graz Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Krause","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases and Tropical Medicine Medical University of Graz Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,7,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/318483"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00029-06"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.05267-11"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2010.01881.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12104"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc6212"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-007-0373-6"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1086\/504810"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001340050286"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/13693786.2011.603102"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2012.10.003"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc9239"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-013-3109-3"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2011.01.002"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1086\/588660"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2011.178"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.2739\/kurumemedj.48.117"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/13693780500474327"},{"key":"e_1_2_6_20_1","doi-asserted-by":"crossref","first-page":"3115","DOI":"10.1128\/jcm.33.12.3115-3118.1995","article-title":"Plasma (1\u2013>3)\u2010beta\u2010D\u2010glucan and fungal antigenemia in patients with candidemia, aspergillosis, and cryptococcosis","volume":"33","author":"Miyazaki T","year":"1995","journal-title":"J Clin Microbiol"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciq206"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000046037"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2002.00162.x"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00658-06"},{"key":"e_1_2_6_25_1","first-page":"1413","article-title":"False\u2010positive endotoxemia derives from gauze glucan after hepatectomy for hepatocellular carcinoma with cirrhosis","volume":"44","author":"Nakao A","year":"1997","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.47479-0"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02473-12"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc12718"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00773-12"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myu023"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199906000-00019"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)92043-6"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201211-2069OC"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00167-13"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00251-13"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2008.01522.x"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e318236f297"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc10507"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01240-10"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.05408-11"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit413"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00467-14"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1130-1406(06)70046-8"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1086\/527382"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)91152-9"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1086\/421944"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1086\/647935"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1086\/521245"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.9.3640-3645.2005"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit073"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12219"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.12.5957-5962.2005"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fmyc.12221","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.12221","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T08:47:52Z","timestamp":1696236472000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/myc.12221"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,15]]},"references-count":51,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["10.1111\/myc.12221"],"URL":"https:\/\/doi.org\/10.1111\/myc.12221","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,15]]}}}