{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T23:03:14Z","timestamp":1787698994428,"version":"build-2784847793"},"reference-count":41,"publisher":"Wiley","issue":"s3","license":[{"start":{"date-parts":[[2014,9,23]],"date-time":"2014-09-23T00:00:00Z","timestamp":1411430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Indian Council of Medical Research, New Delhi, India","award":["ICMR 5\/3\/3\/26\/2010-ECD-I"],"award-info":[{"award-number":["ICMR 5\/3\/3\/26\/2010-ECD-I"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Mucormycosis is a highly aggressive disease which is usually fatal in immunocompromised patients. The species of mucormycetes show significant differences in susceptibility to amphotericin B, azoles and terbinafine. The precise species level identification for this fungal group could be achieved by internal transcribed\u2010spacer (<jats:styled-content style=\"fixed-case\">ITS<\/jats:styled-content>) region sequencing. Herein, we present the largest series of antifungal susceptibility data of molecularly characterised isolates of mucormycetes reported so far from <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>ndia. Eighty isolates originating from 71 patients comprised 50 (62.5%) from pulmonary cases, 15 (19%) from rhino\u2010orbital\u2010cerebral, 13 (16.2%) from cutaneous and 2 (2.5%) from disseminated mucormycosis. ITS and D1\/D2 regions sequencing of the isolates identified, <jats:italic>Rhizopus arrhizus<\/jats:italic> var. <jats:italic>delemar<\/jats:italic> (<jats:italic>n<\/jats:italic>\u00a0=\u00a025), <jats:italic>R. arrhizus<\/jats:italic> var<jats:italic>. arrhizus<\/jats:italic> (<jats:italic>n<\/jats:italic>\u00a0=\u00a015)<jats:italic>, R. microsporus<\/jats:italic> (<jats:italic>n<\/jats:italic>\u00a0=\u00a017), <jats:italic>R. stolonifer<\/jats:italic> (<jats:italic>n<\/jats:italic>\u00a0=\u00a03), <jats:italic>Syncephalastrum racemosum<\/jats:italic> (<jats:italic>n<\/jats:italic>\u00a0=\u00a011), <jats:italic>Apophysomyces elegans<\/jats:italic> (<jats:italic>n<\/jats:italic>\u00a0=\u00a02), <jats:italic>A. variabilis<\/jats:italic> (<jats:italic>n<\/jats:italic>\u00a0=\u00a02), <jats:italic>Lichtheimia ramosa<\/jats:italic> (<jats:italic>n<\/jats:italic>\u00a0=\u00a03) and <jats:italic>Mucor circinelloides<\/jats:italic> f<jats:italic>. lusitanicus<\/jats:italic> (<jats:italic>n<\/jats:italic>\u00a0=\u00a02). Amplified fragment length polymorphism analysis was done to genotype <jats:italic>Rhizopus<\/jats:italic> isolates and revealed 5 clusters of <jats:italic>R. arrhizus<\/jats:italic>, which were well separated from <jats:italic>R. microsporus<\/jats:italic>. Amphotericin B was the most potent antifungal followed by posaconazole, itraconazole and isavuconazole. Etest and CLSI MICs of amphotericin B showed 87% agreement. Overall, the commonest underlying condition was uncontrolled diabetes mellitus. Records of 54 patients revealed fatalities in 28 cases.<\/jats:p>","DOI":"10.1111\/myc.12234","type":"journal-article","created":{"date-parts":[[2014,9,23]],"date-time":"2014-09-23T05:39:08Z","timestamp":1411450748000},"page":"97-107","source":"Crossref","is-referenced-by-count":59,"title":["Molecular characterization and <i>in vitro<\/i> antifungal susceptibility of 80 clinical isolates of mucormycetes in Delhi, India"],"prefix":"10.1111","volume":"57","author":[{"given":"Anuradha","family":"Chowdhary","sequence":"first","affiliation":[{"name":"Department of Medical Mycology Vallabhbhai Patel Chest Institute University of Delhi Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shallu","family":"Kathuria","sequence":"additional","affiliation":[{"name":"Department of Medical Mycology Vallabhbhai Patel Chest Institute University of Delhi Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeep Kumar","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Medical Mycology Vallabhbhai Patel Chest Institute University of Delhi Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brijesh","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Medicine Post Graduate Institute of Medical Education and Research Dr. Ram Manohar Lohia Hospital Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somayeh","family":"Dolatabadi","sequence":"additional","affiliation":[{"name":"CBS\u2010KNAW Fungal Biodiversity Center Utrecht the Netherlands"},{"name":"Institute for Biodiversity and Ecosystem Dynamics University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferry","family":"Hagen","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Infectious Diseases Canisius\u2010Wilhelmina Hospital Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques F.","family":"Meis","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Infectious Diseases Canisius\u2010Wilhelmina Hospital Nijmegen the Netherlands"},{"name":"Department of Medical Microbiology Radboud University Medical Centre Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mycres.2007.03.004"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/423274"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/428780"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/339202"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2009.02973.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1997.3983214.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir866"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.13.2.236"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01467-08"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2009.02984.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01270-09"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00452-07"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.5.1581-1582.2002"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.06133-11"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1086\/500212"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/1040841X.2012.711741"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12371"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.90718"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.riam.2010.01.006"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.6.1953-1959.2002"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.3767\/003158513X665070"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00036-09"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01420-10"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.2307\/3792640"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01863-12"},{"key":"e_1_2_7_27_1","first-page":"315","volume-title":"PCR 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