{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T12:56:16Z","timestamp":1758632176849},"reference-count":19,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,8,18]],"date-time":"2014-08-18T00:00:00Z","timestamp":1408320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Cryptococcosis is an invasive mycotic infection primarily affecting immunocompromised individuals. The objective of this study was to describe cryptococcosis mortality and associated medical conditions in the US for the period 2000\u20132010. Cryptococcosis\u2010related deaths were identified from the national multiple\u2010cause\u2010of\u2010death dataset. Mortality trends and comparison analyses were performed on overall cases of cryptococcosis and by subset [i.e. clinical manifestations of disease and human immunodeficiency virus (<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>) status]. A matched case\u2013control analysis was also conducted to describe the associations between this disease and comorbid medical conditions. A total of 3210 cryptococcosi<jats:italic>s<\/jats:italic>\u2010related deaths were identified. Cerebral cryptococcosis was the most commonly reported clinical manifestation of the disease. Approximately one\u2010fifth of the decedents (<jats:italic>n<\/jats:italic>\u00a0=\u00a0616) had a co\u2010diagnosis of <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>. Mortality rates were highest among men, blacks, Hispanics, Native Americans and older adults. Poisson regression analysis indicated a 6.52% annual decrease in mortality rates for the study period. <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">MOR<\/jats:styled-content>\u00a0=\u00a035.55, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 27.95\u201345.22) and leukaemia (<jats:styled-content style=\"fixed-case\">MOR<\/jats:styled-content>\u00a0=\u00a016.10, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 11.24\u201323.06) were highly associated with cryptococcosis\u2010related deaths. Cryptococcosis mortality declined significantly during 2000\u20132010. However, the disease continues to cause appreciable mortality in the US. With the majority of decedents having no <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> co\u2010diagnosis, there is still much to be learned about the epidemiology of this mycosis.<\/jats:p>","DOI":"10.1111\/myc.12238","type":"journal-article","created":{"date-parts":[[2014,8,19]],"date-time":"2014-08-19T02:27:23Z","timestamp":1408415243000},"page":"741-746","source":"Crossref","is-referenced-by-count":23,"title":["Cryptococcosis\u2010related deaths and associated medical conditions in the United States, 2000\u20132010"],"prefix":"10.1111","volume":"57","author":[{"given":"Noel C.","family":"Barragan","sequence":"first","affiliation":[{"name":"Division of Chronic Disease and Injury Prevention Los Angeles County Department of Public Health Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Sorvillo","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Fielding School of Public Health University of California Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tony","family":"Kuo","sequence":"additional","affiliation":[{"name":"Division of Chronic Disease and Injury Prevention Los Angeles County Department of Public Health Los Angeles CA USA"},{"name":"Department of Epidemiology Fielding School of Public Health University of California Los Angeles CA USA"},{"name":"Department of Family Medicine David Geffen School of Medicine at University of California Los Angeles Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,8,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1128\/CMR.8.4.515","article-title":"Cryptococcosis in the era of AIDS\u2010100\u00a0years after the discovery of Cryptococcus neoformans","volume":"8","author":"Mitchell T","year":"1995","journal-title":"Clin Microbiol Rev"},{"key":"e_1_2_8_3_1","unstructured":"Centers for Disease Control and Prevention National Center for Emerging and Zoonotic Infections Diseases Division of Foodborne Waterborne and Environmental Diseases.Fungal diseases: Cryptococcosis statistics. 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