{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T06:15:19Z","timestamp":1696572919809},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,12,22]],"date-time":"2014-12-22T00:00:00Z","timestamp":1419206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Astellas"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Invasive aspergillosis remains associated with significant morbidity and mortality, necessitating new options for salvage therapy. The objective of this study was to evaluate the efficacy and safety of micafungin as salvage monotherapy in patients with invasive aspergillosis. Patients with proven or probable invasive aspergillosis, who were refractory or intolerant to previous systemic antifungal therapy, were randomised 2\u00a0:\u00a01 to receive 300\u00a0mg\u00a0day<jats:sup>\u22121<\/jats:sup> intravenous micafungin monotherapy or an intravenous control monotherapy [lipid amphotericin B (5\u00a0mg\u00a0kg<jats:sup>\u22121<\/jats:sup>\u00a0day<jats:sup>\u22121<\/jats:sup>), voriconazole (8\u00a0mg\u00a0kg<jats:sup>\u22121<\/jats:sup>\u00a0day<jats:sup>\u22121<\/jats:sup>) or caspofungin (50\u00a0mg\u00a0day<jats:sup>\u22121<\/jats:sup>)] for 3\u201312\u00a0weeks. Patients underwent final assessment 12\u00a0weeks after treatment start. Seventeen patients with invasive aspergillosis (proven, <jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>2; probable, <jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>14; not recorded, <jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>1) participated in the study (micafungin arm, <jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>12; control arm, <jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>5). Three patients each in the micafungin (25.0%; 95% CI: 5.5\u201357.2) and control arm (60.0%; 95% CI: 14.7\u201394.7) had successful therapy at end of treatment as assessed by an Independent Data Review Board. Eleven patients died; six due to invasive aspergillosis. No deaths were considered related to study treatment. During this study it became increasingly common to use combination treatment for salvage therapy. Consequently, enrolment was low and the study was discontinued early. No clear trends in efficacy and safety can be concluded.<\/jats:p>","DOI":"10.1111\/myc.12274","type":"journal-article","created":{"date-parts":[[2014,12,22]],"date-time":"2014-12-22T10:54:02Z","timestamp":1419245642000},"page":"58-64","source":"Crossref","is-referenced-by-count":10,"title":["Randomised, multicentre trial of micafungin vs. an institutional standard regimen for salvage treatment of invasive aspergillosis"],"prefix":"10.1111","volume":"58","author":[{"given":"Oliver A.","family":"Cornely","sequence":"first","affiliation":[{"name":"University of Cologne Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lambertus","family":"Meems","sequence":"additional","affiliation":[{"name":"Astellas Pharma Global Development Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raoul","family":"Herbrecht","sequence":"additional","affiliation":[{"name":"H\u00f4pital de Hautepierre Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Viscoli","sequence":"additional","affiliation":[{"name":"University of Genova (DISSAL) and IRCCS San Martino\u2010IST Genova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald G. 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