{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T16:14:36Z","timestamp":1777652076556,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,1,15]],"date-time":"2015-01-15T00:00:00Z","timestamp":1421280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Invasive aspergillosis (IA) has become increasingly common and is characterised by high morbidity and mortality. Upcoming resistance threatens treatment with azoles and highlights the continuous need for novel therapeutics. This laboratory study investigated the <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> potential of the alkylphospholipid oleylphosphocholine (Ol<jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content>) against <jats:italic>Aspergillus<\/jats:italic>. <jats:italic>In vitro<\/jats:italic> activities of Ol<jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content>, miltefosine, posaconazole and voriconazole were determined for <jats:italic>Aspergillus fumigatus<\/jats:italic>,<jats:italic> A. niger<\/jats:italic>,<jats:italic> A. terreus<\/jats:italic> and <jats:italic>A. flavus<\/jats:italic>. <jats:italic>In vivo<\/jats:italic> efficacy of Ol<jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content> was evaluated in a systemic <jats:italic>A.\u00a0fumigatus<\/jats:italic> mouse model, adopting a short\u2010term and long\u2010term oral or intraperitoneal dosing regimen. Ol<jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content> showed good <jats:italic>in vitro<\/jats:italic> activity against <jats:italic>A. fumigatus<\/jats:italic> (<jats:styled-content style=\"fixed-case\">IC<\/jats:styled-content><jats:sub>50<\/jats:sub>\u00a0=\u00a01.04\u00a0\u03bcmol\u00a0l<jats:sup>\u22121<\/jats:sup>). Intraperitoneal administration of 50\u00a0mg\u00a0kg<jats:sup>\u22121<\/jats:sup>\u00a0day<jats:sup>\u22121<\/jats:sup> Ol<jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content> significantly reduced the fungal organ burdens at 4\u00a0days post\u2010infection (dpi). Although 5\u2010 and 10\u2010day Ol<jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content> treatment improved survival, organ burdens were not affected at 10 and 15\u00a0dpi. While this study showed excellent <jats:italic>in vitro<\/jats:italic> activity of Ol<jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content> against <jats:italic>Aspergillus<\/jats:italic> spp., its therapeutic efficacy in an acute mouse model for IA was less convincing. Given the limited therapeutic options in the current antifungal market for invasive infections, Ol<jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content> activity should be assessed in a less stringent <jats:italic>in vivo<\/jats:italic> model, potentially in combination treatment with other already marketed antifungal drugs.<\/jats:p>","DOI":"10.1111\/myc.12286","type":"journal-article","created":{"date-parts":[[2015,1,15]],"date-time":"2015-01-15T17:47:39Z","timestamp":1421344059000},"page":"127-132","source":"Crossref","is-referenced-by-count":7,"title":["Efficacy of oleylphosphocholine (Ol<scp>PC<\/scp>) <i>in vitro<\/i> and in a mouse model of invasive aspergillosis"],"prefix":"10.1111","volume":"58","author":[{"given":"Caroline","family":"Paulussen","sequence":"first","affiliation":[{"name":"Laboratory of Microbiology, Parasitology and Hygiene (LMPH) Faculty of Pharmaceutical, Biomedical and Veterinary Sciences University of Antwerp Antwerp Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ga\u00eblle","family":"Boulet","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology, Parasitology and Hygiene (LMPH) Faculty of Pharmaceutical, Biomedical and Veterinary Sciences University of Antwerp Antwerp Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom","family":"Bosschaerts","sequence":"additional","affiliation":[{"name":"Dafra Pharma Research &amp; Development Turnhout Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Cos","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology, Parasitology and Hygiene (LMPH) Faculty of Pharmaceutical, Biomedical and Veterinary Sciences University of Antwerp Antwerp Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anny","family":"Fortin","sequence":"additional","affiliation":[{"name":"Dafra Pharma Research &amp; Development Turnhout Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis","family":"Maes","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology, Parasitology and Hygiene (LMPH) Faculty of Pharmaceutical, Biomedical and Veterinary Sciences University of Antwerp Antwerp Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,1,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/513943"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/510535"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/13693780701885552"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2010.06.002"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2009.02929.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1086\/497138"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm428"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit321"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-012-9526-y"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2012.06.021"},{"key":"e_1_2_8_12_1","first-page":"175","article-title":"Epidemiology and treatment approaches in management of invasive fungal infections","volume":"3","author":"Kriengkauykiat J","year":"2011","journal-title":"Clin Epidemiol"},{"key":"e_1_2_8_13_1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1358\/dot.2013.49.3.1921234","article-title":"Current treatment options for invasive aspergillosis","volume":"49","author":"Batista MV","year":"2013","journal-title":"Drugs Today (Barc)"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks273"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.50.2.414-421.2006"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.111.072322"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01382-06"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkt282"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1086\/597772"},{"key":"e_1_2_8_20_1","first-page":"1972","volume-title":"Susceptibility Test Methods: Yeasts and Filamentous Fungi. 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