{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:18:11Z","timestamp":1791303491079,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,1,15]],"date-time":"2015-01-15T00:00:00Z","timestamp":1421280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Key Technologies R&D Program for the 12th Five-year Plan","award":["2012ZX10001003"],"award-info":[{"award-number":["2012ZX10001003"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Two strains of <jats:italic>Cryptococcus neoformans<\/jats:italic> (PU 66 and PU112) were simultaneously isolated from a patient with systemic lupus erythematosus. We aimed to trace the source of the mixed infections. Multi\u2010locus sequence typing (<jats:styled-content style=\"fixed-case\">MLST<\/jats:styled-content>) and the DiversiLab system analyses were performed on the 2 clinical and 23 environmental <jats:italic>C. neoformans<\/jats:italic> from pigeon droppings, 11 from the home (H1) the patient visited, 12 from another home (H2) as control. All the strains were uniformly genotyped as <jats:italic>C. neoformans<\/jats:italic> var. <jats:italic>grubii<\/jats:italic> VNI. Clinical strain PU66 and all the H1 isolates had the same sequence type (<jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>) \u2013 ST5, while for PU112 a new <jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content> was observed \u2013 ST265. However, there was only one single base of 7 <jats:styled-content style=\"fixed-case\">MLST<\/jats:styled-content> loci difference between PU66 and PU112. Sequence types of the H2 strains were ST31 and ST297. DiversiLab analysis showed that strain similarity between the two clinical strains was 96.7%. In relation to environmental samples, the highest strain similarity (99.3%) was observed for PU66 and PU70 (H1). However, none of the environmental isolates had similarity over 98.6% comparing to PU112. One source of the mixed infections has been detected, but another needs further investigation.<\/jats:p>","DOI":"10.1111\/myc.12291","type":"journal-article","created":{"date-parts":[[2015,1,15]],"date-time":"2015-01-15T17:53:43Z","timestamp":1421344423000},"page":"149-159","source":"Crossref","is-referenced-by-count":5,"title":["Application of the DiversiLab system for tracing the source of the mixed infections caused by <i>Cryptococcus neoformans<\/i> var. <i>grubii<\/i> from a patient with systemic lupus erythematosus"],"prefix":"10.1111","volume":"58","author":[{"given":"Hongtao","family":"Dou","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory Peking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingchun","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Peking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taisheng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Peking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,1,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3282a4a64d"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199305063281816"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)92283-N"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/13693780902953886"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2006.07.001"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203309356458"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3062.1999.010309.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2005.01466.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-132-3-200002010-00006"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200503243521225"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciq216"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-010-0045-9"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1086\/426402"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1086\/656685"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2221-1691(11)60195-0"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00091-10"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.9.4766-4772.2005"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.2010.00281.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.34.5.1253-1260.1996"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.33.12.3328-3332.1995"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.32.5.1188-1192.1994"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.2.556-564.2005"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009124"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-009-9230-8"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-004-9618-4"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.03600-13"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0085854"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01664-13"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-014-2099-6"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.47106-0"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01179-12"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.9.4831-4841.2003"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.15.3.535-537.1982"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fgb.2007.12.004"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid0902.020246"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/mst197"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1567-1364.2010.00648.x"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kel343"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01103049"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.1.199-207.2005"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a112628"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.8.4922-4933.2005"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.60.080805.142102"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-10-289"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fmyc.12291","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.12291","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T05:52:36Z","timestamp":1696225956000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/myc.12291"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,15]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1111\/myc.12291"],"URL":"https:\/\/doi.org\/10.1111\/myc.12291","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,15]]}}}