{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T21:17:23Z","timestamp":1792271843955,"version":"4.4.0"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,1,15]],"date-time":"2015-01-15T00:00:00Z","timestamp":1421280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Disseminated histoplasmosis (<jats:styled-content style=\"fixed-case\">DH<\/jats:styled-content>) is the most current revelation mode of <jats:styled-content style=\"fixed-case\">AIDS<\/jats:styled-content> in French Guiana. We describe the clinical and paraclinical presentation of <jats:styled-content style=\"fixed-case\">DH<\/jats:styled-content>, diagnostic tools, evolution and factors associated with 1\u2010year mortality in <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010infected patients from western French Guiana. Microbiologically proven <jats:styled-content style=\"fixed-case\">AIDS<\/jats:styled-content>\u2010related <jats:styled-content style=\"fixed-case\">DH<\/jats:styled-content> in Saint Laurent du Maroni's hospital between May 2002 and May 2012 were retrospectively included. Among the 82 patients included, 58 (71%) were male, 44 (53%) presented concurrent histoplasmosis and <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> diagnosis and 63 (80%) had a <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4 cell count under 50 cells\u00a0\u03bcL<jats:sup>\u22121<\/jats:sup>. Almost all patients had weight loss (97%) and fever (95%), while 84% had digestive symptoms (63% diarrhoea), 55% lymphadenopathy, and 49% respiratory symptoms. Documented and presumed locations of <jats:italic>H. capsulatum var capsulatum (Hcc)<\/jats:italic> concerned almost all organs, with a particular affinity for the bone marrow and the digestive system. Co\u2010infections were associated in 65%. Following treatment initiation, 10 patients (13%) died within 1\u00a0month and 17 patients (25%) died within a year. <jats:styled-content style=\"fixed-case\">DH<\/jats:styled-content> is a polymorphous systemic mycosis with haematological and digestive tropism. Co\u2010infections are frequent and mortality rate is high.<\/jats:p>","DOI":"10.1111\/myc.12293","type":"journal-article","created":{"date-parts":[[2015,1,15]],"date-time":"2015-01-15T17:32:57Z","timestamp":1421343177000},"page":"160-166","source":"Crossref","is-referenced-by-count":19,"title":["<scp>HIV<\/scp>\u2010associated disseminated histoplasmosis in western French Guiana, 2002\u20132012"],"prefix":"10.1111","volume":"58","author":[{"given":"A.","family":"Putot","sequence":"first","affiliation":[{"name":"Department of Medicine Centre Hospitalier de l'Ouest Guyanais Saint Laurent du Maroni French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Perrin","sequence":"additional","affiliation":[{"name":"Department of Medicine Centre Hospitalier de l'Ouest Guyanais Saint Laurent du Maroni French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Jolivet","sequence":"additional","affiliation":[{"name":"Department of Public Health Centre Hospitalier de l'Ouest Guyanais Saint Laurent du Maroni French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Vantilcke","sequence":"additional","affiliation":[{"name":"Department of Medicine Centre Hospitalier de l'Ouest Guyanais Saint Laurent du Maroni French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,1,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199011000-00004"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.qco.0000244049.15888.b9"},{"key":"e_1_2_8_4_1","first-page":"154","article-title":"D\u00e9couvertes de s\u00e9ropositivit\u00e9 VIH et sida \u2010 France, 2003\u20102012","volume":"9","author":"Cazein F","year":"2014","journal-title":"Bull Epid\u00e9miol Hebd"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medmal.2004.05.002"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2011.10-0251"},{"key":"e_1_2_8_7_1","first-page":"181","article-title":"Knowledge, attitudes, beliefs and practices on HIV\/AIDS among boatmen on the maroni river: a neglected bridging group?","volume":"3","author":"Gaubert\u2010Mar\u00e9chal E","year":"2012","journal-title":"J AIDS Clinic Res"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0956462413516299"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1086\/521259"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1086\/428842"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0213-005X(04)73056-6"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.1977.tb01484.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00436457"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1086\/318485"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.40823.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1309\/X0Y2-P3GY-TWE8-DM02"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3282ffde67"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1086\/345724"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.30.8.2104-2107.1992"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.41.9.992"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.116.3008.208"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.44.10.1299"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/21.6.1463"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203310378863"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1987.tb02617.x"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir435"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2009.10.010"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1086\/379770"},{"key":"e_1_2_8_29_1","doi-asserted-by":"crossref","first-page":"600","DOI":"10.4269\/ajtmh.2006.74.600","article-title":"Risk factors for death in acquired immunodeficiency syndrome\u2010associated disseminated histoplasmosis","volume":"74","author":"De Francesco Daher E","year":"2006","journal-title":"Am J Trop Med Hyg"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2008.05.006"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12067"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12175"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fmyc.12293","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.12293","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T05:52:20Z","timestamp":1696225940000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/myc.12293"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,15]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1111\/myc.12293"],"URL":"https:\/\/doi.org\/10.1111\/myc.12293","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,15]]}}}