{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T16:20:00Z","timestamp":1775060400926,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,2,10]],"date-time":"2015-02-10T00:00:00Z","timestamp":1423526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2013R1A1A1A05007037"],"award-info":[{"award-number":["NRF-2013R1A1A1A05007037"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2013R1A1A2007863"],"award-info":[{"award-number":["NRF-2013R1A1A2007863"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerische Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["PA00P3_145360"],"award-info":[{"award-number":["PA00P3_145360"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Advances in culture\u2010independent sequencing methods have been utilised in recent studies to understand the phylogenetic composition of the human microbiome of healthy and diseased skin. Allergic rhinitis (<jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content>) is an inflammatory condition of the nasal cavity caused by environmental allergens. Although nasal microbial communities have been considered important contributors in human health, no studies to date have comprehensively compared fungal communities (mycobiome) of the nasal vestibule using the culture\u2010independent pyrosequencing method. This study aimed to investigate how fungal communities of the nasal vestibule skin surface are influenced by <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content>. The phylogenetic composition of the nasal vestibule mycobiome of patients with <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content> was analysed by culture\u2010independent pyrosequencing methods and compared with healthy individuals. A total of 69 fungal genera were identified from both <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content> samples and healthy controls, and the genus <jats:italic>Malassezia<\/jats:italic> predominated in the nasal vestibule. Species\u2010level analysis classified eight different <jats:italic>Malassezia<\/jats:italic> species including <jats:italic>M. pachydermatis<\/jats:italic> and <jats:italic>M<\/jats:italic>. <jats:italic>cuniculi<\/jats:italic>, which were normally isolated from animals, and revealed <jats:italic>M. restricta<\/jats:italic> to be the most abundant species in the nasal vestibule. Although high interpersonal variation was observed, some of the <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content> samples displayed significantly higher diversities than healthy controls at both the genus and species level.<\/jats:p>","DOI":"10.1111\/myc.12296","type":"journal-article","created":{"date-parts":[[2015,2,12]],"date-time":"2015-02-12T21:56:15Z","timestamp":1423778175000},"page":"167-172","source":"Crossref","is-referenced-by-count":45,"title":["Analysis of the nasal vestibule mycobiome in patients with allergic rhinitis"],"prefix":"10.1111","volume":"58","author":[{"given":"Won Hee","family":"Jung","sequence":"first","affiliation":[{"name":"Department of Systems Biotechnology Chung\u2010Ang University Anseong Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Croll","sequence":"additional","affiliation":[{"name":"Michael Smith Laboratories University of British Columbia Vancouver BC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Hoon","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery School of Medicine Konkuk University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu Ri","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology School of Medicine Konkuk University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang Won","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology School of Medicine Konkuk University Seoul Korea"},{"name":"Research Institute of Medical Science Konkuk University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,2,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60130-X"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1513\/pats.201004-033RN"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01401.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0b013e328010d0db"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.075549.107"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00597-10"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0807920105"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1171700"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010598"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2013.11.005"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.01.016"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2013.04.002"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12171"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.159467.113"},{"key":"e_1_2_7_16_1","first-page":"552","article-title":"Clinical significance of fungi\u2010bearing status of hospitalized patients","volume":"75","author":"Zheng Y","year":"1995","journal-title":"Zhonghua yi xue za zhi"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1130-1406(07)70027-X"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2009.01821.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01541-09"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00062-07"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn879"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbn013"},{"key":"e_1_2_7_23_1","volume-title":"R: A Language and Environment for Statistical Computing","author":"Team RDC","year":"2013"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-98141-3"},{"key":"e_1_2_7_25_1","unstructured":"OksanenJ BlanchetFG KindtRet\u00a0al.vegan: Community Ecology Package. 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