{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T09:11:09Z","timestamp":1696324269129},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,2,10]],"date-time":"2015-02-10T00:00:00Z","timestamp":1423526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Topical antifungal agents which have anti\u2010inflammatory effects have the potential to provide additional clinical benefits. Therefore, an anti\u2010inflammatory activity of lanoconazole (<jats:styled-content style=\"fixed-case\">LCZ<\/jats:styled-content>), a topical antifungal agent, was investigated against <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> models of inflammation. The release of interleukin\u20108 (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20108) from human epidermal keratinocytes stimulated by the addition of 100\u00a0\u03bcg\u00a0ml<jats:sup>\u22121<\/jats:sup> \u03b2\u2010glucan of <jats:italic><jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>accharomyces cerevisiae<\/jats:italic> was significantly inhibited by <jats:styled-content style=\"fixed-case\">LCZ<\/jats:styled-content> at the concentration of 10<jats:sup>\u22125<\/jats:sup>\u00a0mol\u00a0l<jats:sup>\u22121<\/jats:sup>. The release of interferon\u2010\u03b3 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20102 from human peripheral blood mononuclear cells stimulated by the addition of 30 and 100\u00a0\u03bcg\u00a0ml<jats:sup>\u22121<\/jats:sup> phytohemagglutinin was significantly inhibited by <jats:styled-content style=\"fixed-case\">LCZ<\/jats:styled-content> at the concentrations of 10<jats:sup>\u22127<\/jats:sup> and 10<jats:sup>\u22126<\/jats:sup>\u00a0mol\u00a0l<jats:sup>\u22121<\/jats:sup>, respectively. The increase in the ear thickness induced by topical application of 0.01% 12\u2010<jats:italic>O<\/jats:italic>\u2010tetradecanoyl phorbol\u201013\u2010acetate and 1% 2,4,6\u2010trinitrochlorobenzene (<jats:styled-content style=\"fixed-case\">TNCB<\/jats:styled-content>) after sensitisation with 3% <jats:styled-content style=\"fixed-case\">TNCB<\/jats:styled-content> were established as the mouse models of irritant and contact dermatitis, respectively. Application of 1% and 3% <jats:styled-content style=\"fixed-case\">LCZ<\/jats:styled-content> showed a significant anti\u2010inflammatory activity against both the irritant and contact dermatitis models. These findings suggest that <jats:styled-content style=\"fixed-case\">LCZ<\/jats:styled-content> possesses an anti\u2010inflammatory activity, which may be partially helpful in the treatment of dermatomycoses.<\/jats:p>","DOI":"10.1111\/myc.12297","type":"journal-article","created":{"date-parts":[[2015,2,12]],"date-time":"2015-02-12T21:55:43Z","timestamp":1423778143000},"page":"197-202","source":"Crossref","is-referenced-by-count":2,"title":["Anti\u2010inflammatory activity of lanoconazole, a topical antifungal agent"],"prefix":"10.1111","volume":"58","author":[{"given":"Hideya","family":"Uratsuji","sequence":"first","affiliation":[{"name":"Research Laboratories Kyoto R&amp;D Center Maruho Co., Ltd. Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aki","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Research Laboratories Kyoto R&amp;D Center Maruho Co., Ltd. Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihito","family":"Yamada","sequence":"additional","affiliation":[{"name":"Research Laboratories Kyoto R&amp;D Center Maruho Co., Ltd. Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kei","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Research Laboratories Kyoto R&amp;D Center Maruho Co., Ltd. Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsumi","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Research Laboratories Kyoto R&amp;D Center Maruho Co., Ltd. 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