{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:04:37Z","timestamp":1789193077361,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,2,27]],"date-time":"2015-02-27T00:00:00Z","timestamp":1424995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007705","name":"Astellas Pharma Global Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007705","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>We report the <jats:italic>in vitro<\/jats:italic> activity of nine systemically active antifungal agents against 237 contemporary clinical isolates of yeast and moulds obtained from 13 laboratories in China during 2010 through 2012. Susceptibility testing was performed using <jats:styled-content style=\"fixed-case\">CLSI<\/jats:styled-content> methods. Sequencing of <jats:italic>fks<\/jats:italic> hot spots was performed for echinocandin non\u2010wild\u2010type (<jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content>) strains. Isolates included 220 from eight species of <jats:italic>Candida<\/jats:italic>, 15 from four species of <jats:italic>Aspergillus<\/jats:italic> and one isolate each of <jats:italic>Rhodotorula mucilaginosa<\/jats:italic> and <jats:italic>Trichosporon asahii<\/jats:italic>. Resistance to amphotericin B (0.0%), flucytosine (0.0\u20131.7%) and the echinocandins (0.0\u20133.4%) was distinctly uncommon among <jats:italic>C. albicans<\/jats:italic>,<jats:italic> C. parapsilosis<\/jats:italic>,<jats:italic> C.\u00a0tropicalis<\/jats:italic>,<jats:italic> C. glabrata<\/jats:italic> and <jats:italic>C. pelliculosa<\/jats:italic>. Three <jats:italic>C. albicans<\/jats:italic> isolates showed resistance to echinocandins and one harboured a mutation in <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>1 of <jats:italic>fks<\/jats:italic>1. Resistance to the azoles was much more common with resistance to fluconazole, voriconazole and posaconazole detected among isolates of <jats:italic>C. glabrata<\/jats:italic> and <jats:italic>C. tropicalis<\/jats:italic>. Both <jats:italic>C. parapsilosis<\/jats:italic> and <jats:italic>C. pelliculosa<\/jats:italic> exhibited decreased susceptibility to fluconazole. Amphotericin B, the mould\u2010active azoles and the echinocandins were all quite active against isolates of <jats:italic>A. fumigatus<\/jats:italic> and <jats:italic>A. flavus<\/jats:italic>. Consistent with previous studies from China, resistance to fluconazole is prominent among <jats:italic>Candida<\/jats:italic> spp. isolates in this country.<\/jats:p>","DOI":"10.1111\/myc.12299","type":"journal-article","created":{"date-parts":[[2015,2,27]],"date-time":"2015-02-27T12:46:27Z","timestamp":1425041187000},"page":"209-214","source":"Crossref","is-referenced-by-count":35,"title":["<i>In vitro<\/i> antifungal susceptibilities of isolates of <i>Candida<\/i> spp. and <i>Aspergillus<\/i> spp. from China to nine systemically active antifungal agents: data from the SENTRY antifungal surveillance program, 2010 through 2012"],"prefix":"10.1111","volume":"58","author":[{"given":"Michael A.","family":"Pfaller","sequence":"first","affiliation":[{"name":"University of Iowa College of Medicine Iowa City IA USA"},{"name":"JMI Laboratories North Liberty IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Castanheira","sequence":"additional","affiliation":[{"name":"JMI Laboratories North Liberty IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawn A.","family":"Messer","sequence":"additional","affiliation":[{"name":"JMI Laboratories North Liberty IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald N.","family":"Jones","sequence":"additional","affiliation":[{"name":"JMI Laboratories North Liberty IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,27]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3004404"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01130-12"},{"key":"e_1_2_5_4_1","first-page":"153","article-title":"Antibiotics exposure, risk factors, and outcomes with Candida albicans and non\u2010Candida albicans candidemia. 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