{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T11:12:43Z","timestamp":1793445163882,"version":"4.5.0"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,2,27]],"date-time":"2015-02-27T00:00:00Z","timestamp":1424995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Despite improvements in diagnosis and treatment, invasive fungal infections (<jats:styled-content style=\"fixed-case\">IFI<\/jats:styled-content>s) are still a major cause of morbidity and mortality in immunocompromised patients. The data on <jats:styled-content style=\"fixed-case\">IFI<\/jats:styled-content> among children with acute lymphoblastic leukaemia (<jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content>) are still scarce, and our aim was to estimate the risk, aetiology and outcome of proven and probable <jats:styled-content style=\"fixed-case\">IFI<\/jats:styled-content>s in children with <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content> who did not receive primary prophylaxis over an 8\u2010year period. Between January 2005 and February 2013, 125 children who were treated for <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content> at the Pediatric Hematology Department of the Medical School of Ege University were retrospectively reviewed. Proven and probable <jats:styled-content style=\"fixed-case\">IFI<\/jats:styled-content>s were defined according to revised definitions of the European Organization for Research and Treatment of Cancer\/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group. The proven and probable <jats:styled-content style=\"fixed-case\">IFI<\/jats:styled-content> incidence was 30\/125 (24%). Profound neutropenia was detected in 18 (60%) patients, and prolonged neutropenia was detected in 16 (53.3%) of the patients. The most isolated agents were non\u2010<jats:italic>albicans Candida<\/jats:italic> spp. The crude and attributable mortality was 20% and 13.3% respectively. Profound neutropenia was associated with mortality (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). The younger patients were especially at risk for proven <jats:styled-content style=\"fixed-case\">IFI<\/jats:styled-content>. Prolonged neutropenia, to be in the induction phase of chemotherapy, and profound neutropenia were found to be the most common predisposing factors for <jats:styled-content style=\"fixed-case\">IFI<\/jats:styled-content> episodes.<\/jats:p>","DOI":"10.1111\/myc.12303","type":"journal-article","created":{"date-parts":[[2015,2,27]],"date-time":"2015-02-27T12:43:30Z","timestamp":1425041010000},"page":"225-232","source":"Crossref","is-referenced-by-count":28,"title":["Proven and probable invasive fungal infections in children with acute lymphoblastic leukaemia: results from an university hospital, 2005\u20132013"],"prefix":"10.1111","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9189-8220","authenticated-orcid":false,"given":"Zumrut","family":"Sahbudak Bal","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases Department of Pediatrics Faculty of Medicine Ege University Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deniz","family":"Yilmaz Karapinar","sequence":"additional","affiliation":[{"name":"Division of Hematology Department of Pediatrics Faculty of Medicine Ege University Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nihal","family":"Karadas","sequence":"additional","affiliation":[{"name":"Division of Hematology Department of Pediatrics Faculty of Medicine Ege University Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Semra","family":"Sen","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Pediatrics Faculty of Medicine Ege University Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuhal","family":"Onder Sivis","sequence":"additional","affiliation":[{"name":"Division of Hematology Department of Pediatrics Faculty of Medicine Ege University Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayse B.","family":"Akinci","sequence":"additional","affiliation":[{"name":"Division of Hematology Department of Pediatrics Faculty of Medicine Ege University Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Balkan","sequence":"additional","affiliation":[{"name":"Division of Hematology Department of Pediatrics Faculty of Medicine Ege University Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaan","family":"Kavakli","sequence":"additional","affiliation":[{"name":"Division of Hematology Department of Pediatrics Faculty of Medicine Ege University Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadil","family":"Vardar","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Pediatrics Faculty of Medicine Ege University Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yesim","family":"Aydinok","sequence":"additional","affiliation":[{"name":"Division of Hematology Department of Pediatrics Faculty of Medicine Ege University Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/590566"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mph.0000155861.38641.ca"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.23005"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-13-276"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21868"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22750"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.42.7161"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1086\/588660"},{"key":"e_1_2_6_10_1","first-page":"CD006343","article-title":"Antifungal therapy in infants and children with proven, probable or suspected invasive fungal infections","author":"Blyth 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CesaroS DalleJet\u00a0al.ECIL 4 \u2013 Pediatric Group Considerations for Fungal Diseases and Antifungal Treatment in Children. Presented at 4th European Conference on Infections in Leukaemia 8\u201310 Sep 2011."},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.42.7161"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fmyc.12303","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.12303","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T20:05:38Z","timestamp":1696277138000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/myc.12303"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,27]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.1111\/myc.12303"],"URL":"https:\/\/doi.org\/10.1111\/myc.12303","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,27]]}}}