{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:48:45Z","timestamp":1790516925133,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,3,24]],"date-time":"2015-03-24T00:00:00Z","timestamp":1427155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Hospital environment is considered the main source of invasive aspergillosis (IA) in leukemic patients. This study aimed to describe <jats:italic>Aspergillus<\/jats:italic> colonisation in leukemic patients and their hospital environment and to test whether <jats:italic>Aspergillus<\/jats:italic> environmental contamination was associated with IA. For a 2\u2010year period including 14\u2010month renovation work, 91 acute leukaemia inpatients at the hematology department of University hospital in Sousse (Tunisia) were prospectively included. The incidence of probable IA (EORTC\/MSG criteria) was 9.9%. Fifty\u2010six <jats:italic>Aspergillus<\/jats:italic> were isolated from 53 (6.5%) of 811 sputa collected from 35 (38.5%) patients. <jats:italic>Aspergillus<\/jats:italic> spp. were isolated in 59.7% of 494 air samples and in 52.8% of 1579 surface samples taken in the patients' room. <jats:italic>Aspergillus<\/jats:italic> section <jats:italic>Nigri<\/jats:italic> (72.7%) was the most frequent. <jats:italic>Aspergillus<\/jats:italic> contamination peaked in autumn and winter on surface and in summer and autumn in air samples and was higher (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.03) during the renovation work period. Multivariate analysis showed that for each <jats:italic>Aspergillus<\/jats:italic> section <jats:italic>Nigri<\/jats:italic> CFU airborne contamination IA risk increased by 1.05 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.04). In Tunisia, <jats:italic>Aspergillus<\/jats:italic> section <jats:italic>Nigri<\/jats:italic> and <jats:italic>Flavi<\/jats:italic>, but not <jats:italic>Fumigati,<\/jats:italic> are chiefly involved in IA. Our findings support swift implementation of airborne fungal contamination control measures in areas where immunocompromised patient are hospitalised.<\/jats:p>","DOI":"10.1111\/myc.12320","type":"journal-article","created":{"date-parts":[[2015,3,24]],"date-time":"2015-03-24T21:38:27Z","timestamp":1427233107000},"page":"337-342","source":"Crossref","is-referenced-by-count":18,"title":["Hospital environment fungal contamination and aspergillosis risk in acute leukaemia patients in Sousse (Tunisia)"],"prefix":"10.1111","volume":"58","author":[{"given":"Soukeina","family":"Gheith","sequence":"first","affiliation":[{"name":"Service d'Hygi\u00e8ne Hospitali\u00e8re CHU Farhat Hached Sousse Sousse Tunisie"},{"name":"Unit\u00e9 de recherche UR 12SP31 Minist\u00e8re de la Sant\u00e9 Publique Tunis Tunisie"},{"name":"Laboratoire de Parasitologie \u2010Mycologie CHU Farhat Hached Sousse Tunisie"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3293-5276","authenticated-orcid":false,"given":"St\u00e9phane","family":"Ranque","sequence":"additional","affiliation":[{"name":"Laboratoire de Parasitologie \u2010Mycologie CHU Timone\u2010Adultes Assistance Publique\u2010H\u00f4pitaux de Marseille Marseille France"},{"name":"Aix\u2010Marseille Universit\u00e9 IP\u2010TPT UMR MD3 Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wadiaa","family":"Bannour","sequence":"additional","affiliation":[{"name":"Service d'Hygi\u00e8ne Hospitali\u00e8re CHU Farhat Hached Sousse Sousse Tunisie"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosra","family":"Ben Youssef","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9matologie clinique CHU Farhat Hached Sousse 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