{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:48:31Z","timestamp":1790516911321,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,4,17]],"date-time":"2015-04-17T00:00:00Z","timestamp":1429228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The emergence of triazole resistance, including multi\u2010triazole\u2010resistant <jats:italic>Aspergillus fumigatus<\/jats:italic> is being reported around the world, but there has been little evidence of this problem to date in Australia. Here we describe a retrospective search of antifungal susceptibility results of all Australian clinical <jats:italic>A. fumigatus<\/jats:italic> isolates referred to the National Mycology Reference Centre, Adelaide, Australia between 2000 and 2013, yielding 13 isolates with elevated minimum inhibitory concentrations to itraconazole, posaconazole and\/or voriconazole. Four isolates were found to be <jats:italic>Aspergillus lentulus<\/jats:italic>, a closely related, morphologically similar species known to have reduced susceptibility to triazoles. Analysis of the <jats:italic>cyp51A<\/jats:italic> gene of nine confirmed <jats:italic>A. fumigatus<\/jats:italic> isolates revealed two carrying the TR<jats:sub>34<\/jats:sub>\/L98H mutation, one apparently locally acquired in 2004, and the other probably acquired abroad in 2012. Four isolates possessed the G54R, F46Y, Y431S and G448S mutations, respectively, whereas three isolates did not possess known <jats:italic>cyp51A<\/jats:italic> resistance mutations, raising the possibility of other, undetected resistance mechanisms. Routine antifungal susceptibility testing is definitively recommended in patients on long term and sub\u2010therapeutic triazole therapy with breakthrough <jats:italic>Aspergillus<\/jats:italic> infection and recommended for all clinically relevant <jats:italic>A. fumigatus<\/jats:italic> isolates.<\/jats:p>","DOI":"10.1111\/myc.12324","type":"journal-article","created":{"date-parts":[[2015,4,17]],"date-time":"2015-04-17T08:15:13Z","timestamp":1429258513000},"page":"350-355","source":"Crossref","is-referenced-by-count":95,"title":["Multi\u2010triazole\u2010resistant <i>Aspergillus fumigatus<\/i> infections in Australia"],"prefix":"10.1111","volume":"58","author":[{"given":"Sarah E.","family":"Kidd","sequence":"first","affiliation":[{"name":"National Mycology Reference Centre Microbiology &amp; Infectious Diseases SA Pathology Adelaide SA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Goeman","sequence":"additional","affiliation":[{"name":"Department of Microbiology SydPath St. Vincent's Hospital Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques F.","family":"Meis","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology Radboud University Medical Centre Nijmegen The Netherlands"},{"name":"Department of Medical Microbiology and Infectious Diseases Canisius Wilhelmina Hospital Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica A.","family":"Slavin","sequence":"additional","affiliation":[{"name":"Infectious Disease Department Peter MacCallum Cancer Institute Melbourne Vic. 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