{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:08:23Z","timestamp":1772993303363,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,4,7]],"date-time":"2015-04-07T00:00:00Z","timestamp":1428364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior - CAPES","award":["AUX PE PNPD 2386\/2011"],"award-info":[{"award-number":["AUX PE PNPD 2386\/2011"]}]},{"name":"Fundacao de Amparo a Pesquisa do Estado de Minas Gerais - FAPEMIG"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Paracoccidioidomycosis (<jats:styled-content style=\"fixed-case\">PCM<\/jats:styled-content>) is a neglected fungal disease that elicits an important granulomatous inflammatory reaction which aims to isolate the fungi and resolve the infection; besides the innate cellular response, the patients' sera may contain different levels of antibodies directed against <jats:styled-content style=\"fixed-case\">PCM<\/jats:styled-content>'s pathogenic agent: <jats:italic>Paracoccidioides brasiliensis<\/jats:italic> (<jats:italic>Pb<\/jats:italic>). The aim of the study was to assess the distinct serum antibody levels of 19 chronic <jats:styled-content style=\"fixed-case\">PCM<\/jats:styled-content> patients and to associate these levels to the granulomatous inflammatory response and presence of fungi in oral lesions caused by <jats:italic>Pb<\/jats:italic>. The presence of <jats:italic>Pb<\/jats:italic> was detected and counted within oral tissues using immunohistochemistry; antibody levels were classified as negative, low\u2010grade, moderate or high\u2010grade groups. The Kruskal\u2013Wallis and Dunn's test were used to verify possible associations among the groups. Interestingly, lower antibody titres were associated with lesser numbers of <jats:italic>Pb<\/jats:italic>, which favours the cellular response over the humoral response to fight <jats:styled-content style=\"fixed-case\">PCM<\/jats:styled-content>. On the other hand, negative serological results were linked to a higher presence of <jats:italic>Pb<\/jats:italic> in the tissues, indicating that a deficient humoral response supports the fungal proliferation. The number of <jats:italic>Pb<\/jats:italic> was conveniently associated with the level of serum antibodies, showing that the humoral immune response is required, however, not solely responsible to restrain the dissemination of <jats:italic>Pb<\/jats:italic>.<\/jats:p>","DOI":"10.1111\/myc.12325","type":"journal-article","created":{"date-parts":[[2015,4,7]],"date-time":"2015-04-07T12:02:20Z","timestamp":1428408140000},"page":"356-361","source":"Crossref","is-referenced-by-count":6,"title":["Serum antibody levels correlate with oral fungal cell numbers and influence the patients' response to chronic paracoccidioidomycosis"],"prefix":"10.1111","volume":"58","author":[{"given":"Marina Lara","family":"de Carli","sequence":"first","affiliation":[{"name":"Department of Clinic and Surgery School of Dentistry Federal University of Alfenas Alfenas MG Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz Cristina 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