{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T01:10:52Z","timestamp":1784164252220,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,4,23]],"date-time":"2015-04-23T00:00:00Z","timestamp":1429747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The usefulness of posaconazole therapeutic drug monitoring (<jats:styled-content style=\"fixed-case\">TDM<\/jats:styled-content>) is still a matter of debate. A correlation between posaconazole serum levels and breakthrough invasive fungal infections (<jats:styled-content style=\"fixed-case\">IFI<\/jats:styled-content>) has not been clearly demonstrated so far. We analysed posaconazole serum levels in patients with acute myeloid leukaemia (<jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content>) during induction therapy and correlated them with the incidence of breakthrough <jats:styled-content style=\"fixed-case\">IFI<\/jats:styled-content> and the need of systemic antifungal therapy. Overall, 77 <jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content> patients receiving posaconazole were evaluated for serum levels; breakthrough <jats:styled-content style=\"fixed-case\">IFI<\/jats:styled-content> were observed in five with at least one posaconazole <jats:styled-content style=\"fixed-case\">TDM<\/jats:styled-content> (6.5%). Median serum level was 534\u00a0ng\u00a0ml<jats:sup>\u22121<\/jats:sup> (<jats:styled-content style=\"fixed-case\">IQ<\/jats:styled-content> range: 298.5\u2013750.5\u00a0ng\u00a0ml<jats:sup>\u22121<\/jats:sup>) and did not change significantly over time. Four of the 40 patients with median posaconazole levels &lt;500\u00a0ng\u00a0ml<jats:sup>\u22121<\/jats:sup> developed <jats:styled-content style=\"fixed-case\">IFI<\/jats:styled-content>, as compared with only 1 of the 37 patients with median levels \u2265500 (10% vs. 2.7%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.19). Median posaconazole levels on day 7 were 384.5\u00a0ng\u00a0ml<jats:sup>\u22121<\/jats:sup> (<jats:styled-content style=\"fixed-case\">IQ<\/jats:styled-content> range: 207\u2013659\u00a0ng\u00a0ml<jats:sup>\u22121<\/jats:sup>) and 560.5\u00a0ng\u00a0ml<jats:sup>\u22121<\/jats:sup> (<jats:styled-content style=\"fixed-case\">IQ<\/jats:styled-content> range: 395\u2013756\u00a0ng\u00a0ml<jats:sup>\u22121<\/jats:sup>) in patients requiring or not systemic antifungal treatment respectively (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.067). These results seem to confirm that higher median serum levels of posaconazole correlate with higher prophylactic efficacy against proven\/probable <jats:styled-content style=\"fixed-case\">IFI<\/jats:styled-content> and with lesser need of systemic antifungal therapy.<\/jats:p>","DOI":"10.1111\/myc.12326","type":"journal-article","created":{"date-parts":[[2015,4,23]],"date-time":"2015-04-23T09:37:32Z","timestamp":1429781852000},"page":"362-367","source":"Crossref","is-referenced-by-count":32,"title":["Serum posaconazole levels during acute myeloid leukaemia induction therapy: correlations with breakthrough invasive fungal infections"],"prefix":"10.1111","volume":"58","author":[{"given":"Chiara","family":"Cattaneo","sequence":"first","affiliation":[{"name":"Hematology Spedali Civili Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annafranca","family":"Panzali","sequence":"additional","affiliation":[{"name":"Laboratory of Hormonology and Toxicology Spedali Civili Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Passi","sequence":"additional","affiliation":[{"name":"Hematology Spedali Civili Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Borlenghi","sequence":"additional","affiliation":[{"name":"Hematology Spedali Civili Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinzia","family":"Lamorgese","sequence":"additional","affiliation":[{"name":"Hematology Spedali Civili Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Petull\u00e0","sequence":"additional","affiliation":[{"name":"Hematology Spedali Civili Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Re","sequence":"additional","affiliation":[{"name":"Hematology Spedali Civili Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Caimi","sequence":"additional","affiliation":[{"name":"Laboratory of Hormonology and Toxicology Spedali Civili Brescia Italy"},{"name":"Clinical Biochemistry Department of Molecular and Translational Medicine University of Brescia Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Rossi","sequence":"additional","affiliation":[{"name":"Hematology Spedali Civili Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,23]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"1068","article-title":"The epidemiology of fungal infections in patients with hematologic malignancies: the SEIFEM\u20102004 study","volume":"91","author":"Pagano 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