{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T06:02:49Z","timestamp":1789624969036,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,5,21]],"date-time":"2015-05-21T00:00:00Z","timestamp":1432166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Early diagnosis of invasive pulmonary aspergillosis (<jats:styled-content style=\"fixed-case\">IPA<\/jats:styled-content>) remains difficult due to the variable performance of the tests used. We compared the performance characteristics of <jats:italic>Aspergillus<\/jats:italic> lateral flow device (<jats:styled-content style=\"fixed-case\">LFD<\/jats:styled-content>) in bronchoalveolar lavage (<jats:styled-content style=\"fixed-case\">BAL<\/jats:styled-content>) vs. <jats:styled-content style=\"fixed-case\">BAL<\/jats:styled-content>\u2010galactomannan (<jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content>), for the diagnosis of <jats:styled-content style=\"fixed-case\">IPA<\/jats:styled-content>. 311 <jats:styled-content style=\"fixed-case\">BAL<\/jats:styled-content> specimens were prospectively collected from patients who underwent bronchoscopy from January to May 2013. Patients at risk for <jats:styled-content style=\"fixed-case\">IPA<\/jats:styled-content> were divided into haematological malignancy (<jats:styled-content style=\"fixed-case\">HEM<\/jats:styled-content>) and non\u2010<jats:styled-content style=\"fixed-case\">HEM<\/jats:styled-content> groups: solid organ transplants (<jats:styled-content style=\"fixed-case\">SOT<\/jats:styled-content>) (lung transplant (<jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>) and non\u2010<jats:styled-content style=\"fixed-case\">LT SOT<\/jats:styled-content>); chronic steroid use (<jats:styled-content style=\"fixed-case\">CSU<\/jats:styled-content>); solid tumour (<jats:styled-content style=\"fixed-case\">STU<\/jats:styled-content>) and others. We identified 96 patients at risk for <jats:styled-content style=\"fixed-case\">IPA<\/jats:styled-content>; 89 patients (93%) were in the non\u2010<jats:styled-content style=\"fixed-case\">HEM<\/jats:styled-content> groups: <jats:styled-content style=\"fixed-case\">SOT<\/jats:styled-content> 57 (<jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>, 46, non\u2010<jats:styled-content style=\"fixed-case\">LT SOT<\/jats:styled-content>, 11); <jats:styled-content style=\"fixed-case\">CSU<\/jats:styled-content> 21; <jats:styled-content style=\"fixed-case\">STU<\/jats:styled-content> 6, other 5. Only three patients met criteria for <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content> (two probable; one possible). Overall sensitivity (<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>) was 66% for both and specificity (<jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content>) was 94% vs. 52% for <jats:styled-content style=\"fixed-case\">LFD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content> respectively. <jats:styled-content style=\"fixed-case\">LFD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content> performance was similar in the <jats:styled-content style=\"fixed-case\">HEM<\/jats:styled-content> group (<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content> 100% for both and <jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content> 83% vs. 100% respectively). <jats:styled-content style=\"fixed-case\">LFD<\/jats:styled-content> performance was better than <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content> among non\u2010<jats:styled-content style=\"fixed-case\">HEM SOT<\/jats:styled-content> patients (P\u00a0=\u00a00.02). Most false\u2010positive <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content> results occurred in the <jats:styled-content style=\"fixed-case\">SOT<\/jats:styled-content> group (50.8%), especially among <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> patients (56.5%). <jats:styled-content style=\"fixed-case\">LFD<\/jats:styled-content> performance was superior with an overall <jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content> of 95.6% in <jats:styled-content style=\"fixed-case\">SOT<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.002) and 97% in <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> patients (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0008). <jats:styled-content style=\"fixed-case\">LFD<\/jats:styled-content> is a rapid and simple test that can be performed on <jats:styled-content style=\"fixed-case\">BAL<\/jats:styled-content> to rule out <jats:styled-content style=\"fixed-case\">IPA<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/myc.12327","type":"journal-article","created":{"date-parts":[[2015,5,21]],"date-time":"2015-05-21T10:54:05Z","timestamp":1432205645000},"page":"368-374","source":"Crossref","is-referenced-by-count":29,"title":["Performance of lateral flow device and galactomannan for the detection of <i>Aspergillus<\/i> species in bronchoalveolar fluid of patients at risk for invasive pulmonary aspergillosis"],"prefix":"10.1111","volume":"58","author":[{"given":"Marisa H.","family":"Miceli","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases Department of Internal Medicine University of Michigan Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael I.","family":"Goggins","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Internal Medicine Henry Ford Health System Detroit MI 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