{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T12:56:43Z","timestamp":1760014603764,"version":"3.37.3"},"reference-count":19,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,5,11]],"date-time":"2015-05-11T00:00:00Z","timestamp":1431302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004061","name":"Oesterreichische Nationalbank","doi-asserted-by":"publisher","award":["15346"],"award-info":[{"award-number":["15346"]}],"id":[{"id":"10.13039\/501100004061","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Serum 1,3\u2010beta\u2010<jats:sc>d<\/jats:sc>\u2010glucan (<jats:styled-content style=\"fixed-case\">BDG<\/jats:styled-content>) testing is an established diagnostic marker for invasive fungal infections (<jats:styled-content style=\"fixed-case\">IFI<\/jats:styled-content>) among patients with haematological malignancies. In contrast limited data exist regarding the application of urine <jats:styled-content style=\"fixed-case\">BDG<\/jats:styled-content> testing. Same\u2010day midstream urine and serum screening samples were collected in adult patients with underlying haematological malignancies. A total of 80 urine samples from 46 patients were investigated: Twenty\u2010six had positive corresponding serum <jats:styled-content style=\"fixed-case\">BDG<\/jats:styled-content> &gt;120\u00a0pg\u00a0ml<jats:sup>\u22121<\/jats:sup>, 27 intermediate (60\u201380\u00a0pg\u00a0ml<jats:sup>\u22121<\/jats:sup>), and 27 negative serum <jats:styled-content style=\"fixed-case\">BDG<\/jats:styled-content> (&lt;25\u00a0pg\u00a0ml<jats:sup>\u22121<\/jats:sup>). A significant positive correlation between <jats:styled-content style=\"fixed-case\">BDG<\/jats:styled-content> in serum and urine samples was observed (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.025; <jats:italic>r<\/jats:italic>\u00a0=\u00a00.252). Sensitivity, specificity, positive predictive value and negative predictive value (compared with same\u2010day serum results) were: 42%, 76%, 46%, 73% when using an 80\u00a0pg\u00a0ml<jats:sup>\u22121<\/jats:sup> urine cut\u2010off, and 35%, 96%, 82%, 75% for a 250\u00a0pg\u00a0ml<jats:sup>\u22121<\/jats:sup> cut\u2010off. Urine <jats:styled-content style=\"fixed-case\">BDG<\/jats:styled-content> seemed to be higher in samples obtained from patients with probable <jats:styled-content style=\"fixed-case\">IFI<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a013, median 145, <jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content> 22\u2013253) compared to those from patients without <jats:styled-content style=\"fixed-case\">IFI<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a056, median 24, <jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content> 15\u201388) but the difference was not significant (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.069). Overall correlation of same\u2010day urine <jats:styled-content style=\"fixed-case\">BDG<\/jats:styled-content> and serum <jats:styled-content style=\"fixed-case\">BDG<\/jats:styled-content> was moderate. However, urine <jats:styled-content style=\"fixed-case\">BDG<\/jats:styled-content> testing may warrant further investigation in larger studies, as high\u2010positive urine results correlated with high\u2010positive corresponding serum levels and clinical performance was comparable to serum BDG.<\/jats:p>","DOI":"10.1111\/myc.12328","type":"journal-article","created":{"date-parts":[[2015,5,11]],"date-time":"2015-05-11T08:19:35Z","timestamp":1431332375000},"page":"394-398","source":"Crossref","is-referenced-by-count":14,"title":["Detection of (1\u21923)\u2010\u03b2\u2010<scp>D<\/scp>\u2010glucan in same\u2010day urine and serum samples obtained from patients with haematological malignancies"],"prefix":"10.1111","volume":"58","author":[{"given":"Reinhard B.","family":"Raggam","sequence":"first","affiliation":[{"name":"Clinical Institute of Medical and Chemical Laboratory Diagnostics Medical University of Graz Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lara M. L.","family":"Fischbach","sequence":"additional","affiliation":[{"name":"Section\u00a0of Infectious Diseases and Tropical Medicine Medical University of Graz Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juergen","family":"Prattes","sequence":"additional","affiliation":[{"name":"Section\u00a0of Infectious Diseases and Tropical Medicine Medical University of Graz Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wiebke","family":"Duettmann","sequence":"additional","affiliation":[{"name":"Section\u00a0of Infectious Diseases and Tropical Medicine Medical University of Graz Graz Austria"},{"name":"Division of Haematology Department of Internal Medicine Medical University of Graz Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Eigl","sequence":"additional","affiliation":[{"name":"Section\u00a0of Infectious Diseases and Tropical Medicine Medical University of Graz Graz Austria"},{"name":"Division of Pulmonology Department of Internal Medicine Medical University of Graz Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederike","family":"Reischies","sequence":"additional","affiliation":[{"name":"Section\u00a0of Infectious Diseases and Tropical Medicine Medical University of Graz Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert","family":"W\u00f6lfler","sequence":"additional","affiliation":[{"name":"Division of Haematology Department of Internal Medicine Medical University of Graz Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasmin","family":"Rabensteiner","sequence":"additional","affiliation":[{"name":"Clinical Institute of Medical and Chemical Laboratory Diagnostics Medical University of Graz Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Prueller","sequence":"additional","affiliation":[{"name":"Clinical Institute of Medical and Chemical Laboratory Diagnostics Medical University of Graz Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Krause","sequence":"additional","affiliation":[{"name":"Clinical Institute of Medical and Chemical Laboratory Diagnostics Medical University of Graz Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Hoenigl","sequence":"additional","affiliation":[{"name":"Section\u00a0of Infectious Diseases and Tropical Medicine Medical University of Graz Graz Austria"},{"name":"Division of Pulmonology Department of Internal Medicine Medical University of Graz Graz Austria"},{"name":"Division of Infectious Diseases Department of Medicine University of California San Diego San Diego USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,5,11]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"1068","article-title":"The epidemiology of fungal infections in patients with hematologic malignancies: the SEIFEM\u20102004 study","volume":"91","author":"Pagano L","year":"2006","journal-title":"Haematologica"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2010.01881.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00467-14"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2011.10.008"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-108-1-88"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc6212"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-4453(96)92700-0"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2011.178"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myu023"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1086\/527382"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12221"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12039"},{"key":"e_1_2_7_14_1","unstructured":"PounderJI OguraN FinkelmanMA WoodsG.Utility of (1\u21923)\u2010\u00df\u2010Glucan Detection in Urine using the Fungitell Assay.105th General Meeting of the American Society for Microbiology(ASM); 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