{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T21:50:05Z","timestamp":1792273805708,"version":"4.4.0"},"reference-count":132,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2015,5,29]],"date-time":"2015-05-29T00:00:00Z","timestamp":1432857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The epidemiology of <jats:italic>Candida<\/jats:italic> infections has changed in recent years. Although <jats:italic>Candida albicans<\/jats:italic> is still the main cause of invasive candidiasis in most clinical settings, a substantial proportion of patients is now infected with non\u2010<jats:italic>albicans Candida<\/jats:italic> species. The various <jats:italic>Candida<\/jats:italic> species vary in their susceptibility to the most commonly used antifungal agents, and the intrinsic resistance to antifungal therapy seen in some species, along with the development of acquired resistance during treatment in others, is becoming a major problem in the management of <jats:italic>Candida<\/jats:italic> infection. A better understanding of the mechanisms and clinical impact of antifungal drug resistance is essential for the efficient treatment of patients with <jats:italic>Candida<\/jats:italic> infection and for\u00a0improving treatment outcomes. Herein, we report resistance to the azoles and echinocandins among <jats:italic>Candida<\/jats:italic> species.<\/jats:p>","DOI":"10.1111\/myc.12330","type":"journal-article","created":{"date-parts":[[2015,5,29]],"date-time":"2015-05-29T19:30:24Z","timestamp":1432927824000},"page":"2-13","source":"Crossref","is-referenced-by-count":361,"title":["Antifungal drug resistance among <i>Candida<\/i> species: mechanisms and clinical impact"],"prefix":"10.1111","volume":"58","author":[{"given":"Maurizio","family":"Sanguinetti","sequence":"first","affiliation":[{"name":"Institute of Microbiology Universit\u00e0 Cattolica del Sacro Cuore Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brunella","family":"Posteraro","sequence":"additional","affiliation":[{"name":"Institute of Public Health Section\u00a0of Hygiene Universit\u00e0 Cattolica del Sacro Cuore Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia","family":"Lass\u2010Fl\u00f6rl","sequence":"additional","affiliation":[{"name":"Division of Hygiene and Medical Microbiology Innsbruck Medical University Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,5,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCC.0b013e32833e84d2"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e318206c1ca"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/421946"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/313450"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.4.1298-1302.2002"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis697"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-8579(08)70006-2"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid0908.030069"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.4.1829-1835.2005"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00029-06"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2006.01.002"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.47239-0"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-10-312"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1086\/342300"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1086\/529435"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181760f42"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365540701765657"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02117-09"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2011.02.016"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01128-10"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkn381"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq136"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00479-10"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq053"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.169.4.379"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2006.07.004"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00029-06"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2008.01978.x"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2009.01691.x"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/2047-783X-16-4-187"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12539"},{"key":"e_1_2_10_33_1","first-page":"661","article-title":"Candidemia in intensive care unit: a nationwide prospective observational survey (GISIA\u20103 study) and review of the European literature from 2000 through 2013","volume":"18","author":"Montagna MT","year":"2014","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2010.04.006"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1086\/524071"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/24.2.235"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12039"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dki310"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.10.3149-3154.2003"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01140-07"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01901-07"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00566-08"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01256-09"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2011.01.004"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2009.02821.x"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01889-08"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00690-11"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02120-10"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.44.2.324-326.2006"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.50.4.1148-1155.2006"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.06112-11"},{"key":"e_1_2_10_52_1","unstructured":"Clinical and Laboratory Standards Institute.Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts; Approved Standard \u2013Third Edition. CLSI document M27\u2010A3.Wayne PA:Clinical and Laboratory Standards Institute 2008."},{"key":"e_1_2_10_53_1","unstructured":"Clinical and Laboratory Standards Institute.Method for Antifungal Disk Diffusion Susceptibility Testing of Yeasts; Approved Guidelines \u2013Second Edition. CLSI document M44\u2010A2.Wayne PA:Clinical and Laboratory Standards Institute 2009."},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2012.03880.x"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02445-09"},{"key":"e_1_2_10_56_1","unstructured":"Clinical and Laboratory Standards Institute.Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts; Fourth Informational Supplement. CLSI document M27\u2010S4.Wayne PA:Clinical and Laboratory Standards Institute 2012."},{"key":"e_1_2_10_57_1","unstructured":"European Committee on Antimicrobial Susceptibility Testing.Antifungal Agents: Breakpoint tables for interpretation of MICs. Version 6.1 valid from 2013\u201003\u201011.2013."},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.14.55"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00224-12"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00903-13"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2006.01243.x"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-011-1390-z"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.054445-0"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0033818"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2011.11.001"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.40.12.2835"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-143-2-405"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.11.2378"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.7.1482"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.1997.tb12580.x"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.10.2645"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.11.2932"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(96)01360-9"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1R020"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2007.04.002"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.8.3264-3273.2005"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00802-08"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01162-08"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00443-09"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2007.05588.x"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000040"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.9.3407-3411.2004"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.12.5146-5148.2005"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00563-06"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00095-07"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00999-10"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00123-14"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00200-11"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.105.054767"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00129-11"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.183.10.2971-2978.2001"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.10.3551-3557.2002"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00409-07"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01915-07"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2010.06.015"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2010.08.013"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01079-10"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00308-13"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00148-06"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1086\/500939"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl022"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1592\/phco.26.6.877"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm095"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01568-07"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000173771.47698.7b"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02390-09"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.1086\/496935"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1086\/502581"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2013.08.010"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12281-010-0013-y"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2007.01812.x"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-007-0339-8"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2008.10.035"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00179-11"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0b013e3181607262"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2008.02653.x"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2009.01787.x"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc11307"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-007-0865-y"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181cc4734"},{"key":"e_1_2_10_121_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc9033"},{"key":"e_1_2_10_122_1","doi-asserted-by":"publisher","DOI":"10.3109\/13693786.2012.686673"},{"key":"e_1_2_10_123_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-6-21"},{"key":"e_1_2_10_124_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2011.02044.x"},{"key":"e_1_2_10_125_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-013-0432-0"},{"key":"e_1_2_10_126_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024198"},{"key":"e_1_2_10_127_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12077"},{"key":"e_1_2_10_128_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-007-0448-4"},{"key":"e_1_2_10_129_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks019"},{"key":"e_1_2_10_130_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268809991531"},{"key":"e_1_2_10_131_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-010-9322-5"},{"key":"e_1_2_10_132_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365540903321572"},{"key":"e_1_2_10_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2011.06.006"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fmyc.12330","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.12330","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T08:55:26Z","timestamp":1694681726000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/myc.12330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,29]]},"references-count":132,"journal-issue":{"issue":"S2","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["10.1111\/myc.12330"],"URL":"https:\/\/doi.org\/10.1111\/myc.12330","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,29]]}}}