{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T12:00:21Z","timestamp":1789905621052,"version":"4.0.1"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,5,25]],"date-time":"2015-05-25T00:00:00Z","timestamp":1432512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>This single\u2010centre retrospective cohort study evaluated the incidence and outcome of mycoses in critical ill patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a0283) with sepsis due to peritonitis. Overall mortality was 41.3%, and the 28\u2010day mortality was 29.3%. Fungal pathogens were found in 51.9%. The common first location was the respiratory tract (66.6%), followed by the abdominal site (19.7%). <jats:italic>Candida<\/jats:italic> colonisation was found in 64.6%, and invasive <jats:italic>Candida<\/jats:italic> infection in 34.0%. Identified fungi were <jats:italic>Candida<\/jats:italic> spp. in 98.6% and <jats:italic>Aspergillus<\/jats:italic> spp. in 6.1%. Patients with fungal pathogens showed a higher rate of postoperative peritonitis, <jats:styled-content style=\"fixed-case\">APACHE II<\/jats:styled-content> and tracheotomy. In comparison to patients without fungal pathogens, these patients showed a longer duration on mechanical ventilation, and a higher overall mortality. Patients with <jats:italic>Candida<\/jats:italic>\u2010positive swabs from abdominal sites had more fascia dehiscence and anastomosis leakage. Seventy\u2010two patients (48.9%) received antifungal therapy, 26 patients were treated empirically. Antifungal therapy was not associated with a decrease in mortality. Age and renal replacement therapy were associated with mortality. In conclusion, fungi are common pathogens in critically ill patients with peritonitis, and detection of fungi is associated with an increase in overall mortality. Particularly, <jats:italic>Candida<\/jats:italic>\u2010positive abdominal swabs are associated with an increase in morbidity. However, we were not able to demonstrate a survival benefit for antifungal therapy in peritonitis patients.<\/jats:p>","DOI":"10.1111\/myc.12331","type":"journal-article","created":{"date-parts":[[2015,5,25]],"date-time":"2015-05-25T20:08:56Z","timestamp":1432584536000},"page":"399-407","source":"Crossref","is-referenced-by-count":23,"title":["Relevance of <i>Candida<\/i> and other mycoses for morbidity and mortality in severe sepsis and septic shock due to peritonitis"],"prefix":"10.1111","volume":"58","author":[{"given":"Christoph","family":"Lichtenstern","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Heidelberg University Hospital Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Herold","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Heidelberg University Hospital Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Mieth","sequence":"additional","affiliation":[{"name":"Department of General Visceral and Transplant Surgery Heidelberg University Hospital Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorsten","family":"Brenner","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Heidelberg University Hospital Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Decker","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Heidelberg University Hospital Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelius J.","family":"Busch","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Heidelberg University Hospital Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Hofer","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Heidelberg University Hospital Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Zimmermann","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Medical Microbiology and Hygiene Heidelberg University Hospital Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus A.","family":"Weigand","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Heidelberg University Hospital Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Bernhard","sequence":"additional","affiliation":[{"name":"Emergency Department University of Leipzig Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,5,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1208623"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000261890.41311.E9"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022139"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200107000-00002"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e318232db65"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1754"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.5833"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00101-009-1655-4"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1086\/649554"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-013-3109-3"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2010.10.021"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.101.6.1481"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000201889.39443.D2"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc7931"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2010.03360.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000053525.49267.77"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00029-06"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm145"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1086\/525258"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2012.239"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1086\/321811"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.3109\/10408410903241444"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-007-0270-z"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc8110"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12039"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1086\/596757"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12038"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1086\/588660"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fmyc.12331","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.12331","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T22:18:56Z","timestamp":1696198736000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/myc.12331"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,25]]},"references-count":28,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1111\/myc.12331"],"URL":"https:\/\/doi.org\/10.1111\/myc.12331","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,25]]}}}