{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:41:43Z","timestamp":1787164903721,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,7,7]],"date-time":"2015-07-07T00:00:00Z","timestamp":1436227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001238","name":"The Merck Company Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001238","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Invasive mould infection (\n                    <jats:styled-content style=\"fixed-case\">IMI<\/jats:styled-content>\n                    ) is an important cause of morbidity and mortality in immunocompromised patients. However, Swedish epidemiology data are lacking. The aim of this study was to investigate the epidemiology and outcome of\n                    <jats:styled-content style=\"fixed-case\">IMI<\/jats:styled-content>\n                    . Cases of proven\/probable\n                    <jats:styled-content style=\"fixed-case\">IMI<\/jats:styled-content>\n                    at Karolinska University Hospital, Stockholm, from 2005 to 2009, were included. A total of 100 patients with 104 episodes of\n                    <jats:styled-content style=\"fixed-case\">IMI<\/jats:styled-content>\n                    were enrolled. Identified isolates included 101 mould isolates. The majority of the isolates were\n                    <jats:italic>Aspergillus<\/jats:italic>\n                    spp. (74.3%), followed by\n                    <jats:italic>Mucorales<\/jats:italic>\n                    spp. (13.9%),\n                    <jats:italic>Fusarium<\/jats:italic>\n                    spp. (4.9%) and other mould spp. (6.9%). In 13% of the episodes, more than one mould caused the\n                    <jats:styled-content style=\"fixed-case\">IMI<\/jats:styled-content>\n                    . The lung was most often affected (88.5%). The most frequent underlying disease was haematological malignancies (70%). Following diagnosis, 83.7% initially received antifungal monotherapy, 9.6% received combination therapy and 6.7% no treatment. The overall 90\u2010day and 1\u2010year overall survival was 49% and 46% respectively. Survival at 90\u00a0days post diagnosis was 71.4% in the solid tumour cohort, 62.5% in patients with solid organ transplants, 43.5% in haematological malignancy (\n                    <jats:styled-content style=\"fixed-case\">HM<\/jats:styled-content>\n                    s) and 37% in those undergoing allogeneic haematopoietic stem cell transplantation (\n                    <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>\n                    ). Overall survival was poor in the studied cohort, but is variable among different host categories, with particular opportunities for improvement in patients with underlying\n                    <jats:styled-content style=\"fixed-case\">HM<\/jats:styled-content>\n                    s and allogeneic\n                    <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>\n                    .\n                  <\/jats:p>","DOI":"10.1111\/myc.12344","type":"journal-article","created":{"date-parts":[[2015,7,7]],"date-time":"2015-07-07T13:22:00Z","timestamp":1436275320000},"page":"470-477","source":"Crossref","is-referenced-by-count":39,"title":["Epidemiology and outcomes of patients with invasive mould infections: a retrospective observational study from a single centre (2005\u20132009)"],"prefix":"10.1111","volume":"58","author":[{"given":"Lena","family":"Klingspor","sequence":"first","affiliation":[{"name":"Division of Clinical Microbiology Karolinska Institutet Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baharak","family":"Saaedi","sequence":"additional","affiliation":[{"name":"Division of Clinical Microbiology Karolinska Institutet Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Ljungman","sequence":"additional","affiliation":[{"name":"Division of Haematology Karolinska Institutet Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attila","family":"Szakos","sequence":"additional","affiliation":[{"name":"Division of Pathology Karolinska Institutet Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12060"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir866"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2012.08.003"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-014-2111-1"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1086\/588660"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2010.00499.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1086\/657065"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1086\/522189"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1086\/651263"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40261-012-0022-4"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2004.03.068"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2002.36193"},{"issue":"1","key":"e_1_2_7_14_1","first-page":"S16","article-title":"Pathogenesis of mucormycosis","volume":"54","author":"Ashraf SI","year":"2012","journal-title":"Clin Infect Dis"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.18.3.556-569.2005"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2010.03456.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00286-10"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2010.01.010"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00014-07"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12409"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2011.03548.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12161"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fmyc.12344","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.12344","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T16:35:18Z","timestamp":1696264518000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/myc.12344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,7]]},"references-count":21,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.1111\/myc.12344"],"URL":"https:\/\/doi.org\/10.1111\/myc.12344","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,7]]}}}