{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T15:48:39Z","timestamp":1762098519402,"version":"3.41.0"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,7,7]],"date-time":"2015-07-07T00:00:00Z","timestamp":1436227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The purposes of this study were to investigate the enzymatic activity of different<jats:italic>Candida<\/jats:italic>species and their antifungal susceptibility patterns. The study involved a total of 83 isolates of<jats:italic>Candida<\/jats:italic>from the genital tract of the female<jats:italic>Camelus dromedarius<\/jats:italic>. After species identification, the isolates were analysed for the production\/activity of phospholipase, proteinase and haemolysin. In addition, the agar disc diffusion method was performed on the basis of<jats:styled-content style=\"fixed-case\">CLSI<\/jats:styled-content>guidelines M44\u2010A2 protocol for antifungal susceptibility testing. All the isolates were able to produce phospholipase, proteinase and haemolysin. A total of 35.48%, 87.09% and 64.51% of<jats:italic>C.\u00a0albicans<\/jats:italic>isolates exhibited very high phospholipase, proteinase and haemolytic activities, respectively, whereas very high phospholipase, proteinase and haemolytic activities were determined in 5.76%, 23.07% and 45.16% of non\u2010<jats:italic>C.\u00a0albicans<\/jats:italic>isolates respectively. Overall, 61 (73.5%) of<jats:italic>Candida<\/jats:italic>isolates were susceptible to fluconazole, 70 (84.3%) susceptible to clotrimazole, 82 (98.8%) susceptible to voriconazole, 76 (91.6%) susceptible to itraconazole, 75 (90.4%) susceptible to ketoconazole, 83 (100%) susceptible to amphotericin B, 81 (97.6%) susceptible to nystatin and 36 (43.4%) susceptible to flucytosine.<jats:italic>Candida<\/jats:italic>isolates showed higher haemolytic activity than that of other secreted hydrolases among vaginal<jats:italic>Candida<\/jats:italic>species. In addition, amphotericin B was the most<jats:italic>in\u00a0vitro<\/jats:italic>effective antifungal drug and flucytosine had the poorest activity under such conditions.<\/jats:p>","DOI":"10.1111\/myc.12345","type":"journal-article","created":{"date-parts":[[2015,7,7]],"date-time":"2015-07-07T17:21:18Z","timestamp":1436289678000},"page":"478-484","source":"Crossref","is-referenced-by-count":6,"title":["Evaluation of virulence factors and antifungal susceptibility patterns of different<i>Candida<\/i>species isolated from the female camel (<i>Camelus dromedarius<\/i>) genital tract"],"prefix":"10.1111","volume":"58","author":[{"given":"Aghil","family":"Sharifzadeh","sequence":"first","affiliation":[{"name":"Faculty of Veterinary Medicine Mycology Research Center University of Tehran Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minoo","family":"Soltani","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine Mycology Research Center 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