{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T04:42:12Z","timestamp":1789879332229,"version":"4.0.1"},"reference-count":22,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,7,22]],"date-time":"2015-07-22T00:00:00Z","timestamp":1437523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Atopic patients with chronic obstructive pulmonary disease (<jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content>) demonstrate more severe symptoms than their non\u2010atopic counterparts. Also, <jats:italic>Aspergillus<\/jats:italic> hypersensitivity is known in <jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content>. However, allergic sensitisation to non\u2010<jats:italic>Aspergillus<\/jats:italic>\u00a0fungi has never been studied in <jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content> patients. To evaluate the prevalence of fungal sensitisation and its impact on the clinical presentation and outcome of <jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content> patients. Sensitisation to 17 fungi was studied in 55 <jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content> patients through skin prick tests, fungus\u2010specific IgE, precipitating antibodies, total IgE and eosinophil counts. The clinical symptoms of patients were monitored thorough a patient\u2010administered questionnaire. Overall, 5.4% (<jats:italic>n<\/jats:italic>\u00a0=\u00a03) of <jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content> patients were fungus sensitive. The sensitisation was noted to <jats:italic>Alternaria alternata<\/jats:italic>\u00a0and\u00a0<jats:italic>Schizophyllum commune<\/jats:italic>\u00a0in two patients each, whereas another was sensitive to <jats:italic>A.\u00a0tamarii<\/jats:italic>,<jats:italic> Rhizopus<\/jats:italic>\u00a0spp. and\u00a0<jats:italic>Aspergillus fumigatus<\/jats:italic>. Eosinophils were higher in fungus\u2010sensitised patients (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001 vs. 0.003). No differences were noted in the clinical presentation of patients sensitised to fungi compared to those not sensitised to fungi or non\u2010atopic. Although low, fungal sensitisation occurs in <jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content> but it is not limited to Aspergilli alone. Fungus\u2010sensitised patients exhibit greater eosinophilia, implying more severe inflammation. Thus, such patients should be followed up regularly to recognise clinical worsening or development of <jats:styled-content style=\"fixed-case\">ABPM<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/myc.12352","type":"journal-article","created":{"date-parts":[[2015,7,22]],"date-time":"2015-07-22T15:47:17Z","timestamp":1437580037000},"page":"531-535","source":"Crossref","is-referenced-by-count":19,"title":["The role of fungal sensitisation in clinical presentation in patients with chronic obstructive pulmonary disease"],"prefix":"10.1111","volume":"58","author":[{"given":"Kshitij","family":"Agarwal","sequence":"first","affiliation":[{"name":"Department of Pulmonary Medicine Vallabhbhai Patel Chest Institute University of Delhi Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shailendra Nath","family":"Gaur","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Vallabhbhai Patel Chest Institute University of Delhi Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anuradha","family":"Chowdhary","sequence":"additional","affiliation":[{"name":"Department of Medical Mycology Vallabhbhai Patel Chest Institute University of Delhi Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00074705"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/1040841X.2012.754401"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201211-2103OC"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2007.01432.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/13693781003743148"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/0972-6691.104442"},{"key":"e_1_2_7_8_1","unstructured":"Executive Summary: Global Strategy for Diagnosis Management and Prevention of Chronic Obstructive Pulmonary Disease(updated 2010). 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