{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:10:58Z","timestamp":1790082658089,"version":"4.0.1"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,7,27]],"date-time":"2015-07-27T00:00:00Z","timestamp":1437955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Posaconazole was introduced as the primary antifungal prophylaxis (<jats:styled-content style=\"fixed-case\">PAP<\/jats:styled-content>) in acute myeloid leukaemia (<jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content>) or myelodysplastic syndrome (<jats:styled-content style=\"fixed-case\">MDS<\/jats:styled-content>) patients during remission induction chemotherapy. Data on breakthrough invasive fungal infections (<jats:styled-content style=\"fixed-case\">IFI<\/jats:styled-content>s) from various centres are essential, as there are several considerations in treating <jats:styled-content style=\"fixed-case\">IFI<\/jats:styled-content>s in the posaconazole era. The aim of this study was to evaluate the effectiveness of posaconazole <jats:styled-content style=\"fixed-case\">PAP<\/jats:styled-content> and identify characteristics of <jats:styled-content style=\"fixed-case\">IFI<\/jats:styled-content>s at a single centre in Korea. We retrospectively reviewed consecutive patients with <jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">MDS<\/jats:styled-content> undergoing remission induction chemotherapy between December 2010 and November 2013. Of the 424 patients, 140 received posaconazole and 284 received fluconazole prophylaxis. The incidence of breakthrough proven\/probable <jats:styled-content style=\"fixed-case\">IFI<\/jats:styled-content>s (15.5% vs. 2.9%, <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001) and empirical antifungal treatment (<jats:styled-content style=\"fixed-case\">EAFT<\/jats:styled-content>) (45.8% vs. 12.9%, <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001) decreased in the posaconazole group compared to the fluconazole group. In the posaconazole <jats:styled-content style=\"fixed-case\">PAP<\/jats:styled-content> group, two cases of breakthrough mucormycosis were noted among 13 proven\/probable\/possible <jats:styled-content style=\"fixed-case\">IFI<\/jats:styled-content> cases (15.4%). Overall and <jats:styled-content style=\"fixed-case\">IFI<\/jats:styled-content>\u2010related mortality was 12.1% and 1.9% respectively. Fungus\u2010free survival was significantly higher in the posaconazole group (74.7% vs. 87.1%, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.028). Breakthrough <jats:styled-content style=\"fixed-case\">IFI<\/jats:styled-content>s and <jats:styled-content style=\"fixed-case\">EAFT<\/jats:styled-content> decreased significantly after posaconazole <jats:styled-content style=\"fixed-case\">PAP<\/jats:styled-content>. The benefit in fungus\u2010free survival was noted with posaconazole <jats:styled-content style=\"fixed-case\">PAP<\/jats:styled-content>. Clinicians should be vigilant to identify non\u2010<jats:italic>Aspergillus <\/jats:italic><jats:styled-content style=\"fixed-case\">IFI<\/jats:styled-content>s with active diagnostic effort.<\/jats:p>","DOI":"10.1111\/myc.12357","type":"journal-article","created":{"date-parts":[[2015,7,27]],"date-time":"2015-07-27T14:24:39Z","timestamp":1438007079000},"page":"565-571","source":"Crossref","is-referenced-by-count":24,"title":["Posaconazole for primary antifungal prophylaxis in patients with acute myeloid leukaemia or myelodysplastic syndrome during remission induction chemotherapy: a single\u2010centre retrospective study in Korea and clinical considerations"],"prefix":"10.1111","volume":"58","author":[{"given":"Sung\u2010Yeon","family":"Cho","sequence":"first","affiliation":[{"name":"Vaccine Bio Research Institute College of Medicine The Catholic University of Korea Seoul Korea"},{"name":"Division of Infectious Diseases Department of Internal Medicine College of Medicine The Catholic 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