{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T07:42:00Z","timestamp":1696232520290},"reference-count":9,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,9,7]],"date-time":"2015-09-07T00:00:00Z","timestamp":1441584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Galderma Laboratorium GmbH, Germany"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Topical monotherapy is a valid therapeutic approach in onychomycosis. Due to its lengthy course and its non\u2010reimbursed product status, cost and compliance are important issues and non\u2010pharmacological properties such as over\u2010the\u2010counter price and ease of use should be considered when deciding which product to recommend. We investigated surrogate parameters for patient\u2010friendliness and treatment cost in Germany in a questionnaire\u2010based prospective, comparative, intra\u2010individual, open\u2010label trial of the two common topical antifungal nail lacquers Loceryl<jats:sup>\u00ae<\/jats:sup> (amorolfine 5%) and Ciclopoli<jats:sup>\u00ae<\/jats:sup> (ciclopirox 8%) in eight patients with clinically diagnosed onychomycosis. The 2.5\u00a0ml bottle of Loceryl<jats:sup>\u00ae<\/jats:sup> covered a treatment period of 308\u00a0days, resulting in treatment costs of \u20ac0.10 per day in comparison to the 3.3\u00a0ml bottle of Ciclopoli<jats:sup>\u00ae<\/jats:sup>, covering 127\u00a0days at \u20ac0.21 per day, given once\u2010daily application for Ciclopoli<jats:sup>\u00ae<\/jats:sup> and once\u2010weekly application for Loceryl<jats:sup>\u00ae<\/jats:sup> in accordance with regulatory approval. Six out of eight patients favoured the Loceryl<jats:sup>\u00ae<\/jats:sup> treatment regimen. Furthermore, four out of eight patients found Loceryl<jats:sup>\u00ae<\/jats:sup> easier to apply, whereas three preferred Ciclopoli<jats:sup>\u00ae<\/jats:sup>. In total, seven out of eight stated a clear preference for Loceryl<jats:sup>\u00ae<\/jats:sup> over Ciclopoli<jats:sup>\u00ae<\/jats:sup>. Loceryl<jats:sup>\u00ae<\/jats:sup> therapy is less expensive and less time\u2010consuming. The therapeutic period that can be covered is longer and more patients stated a clear preference for Loceryl<jats:sup>\u00ae<\/jats:sup> in comparison to Ciclopoli<jats:sup>\u00ae<\/jats:sup>. The differences are statistically significant, underlining probable clinical relevance.<\/jats:p>","DOI":"10.1111\/myc.12371","type":"journal-article","created":{"date-parts":[[2015,9,7]],"date-time":"2015-09-07T08:06:27Z","timestamp":1441613187000},"page":"632-636","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of user\u2010friendliness and treatment cost of Loceryl<sup>\u00ae<\/sup> vs. Ciclopoli<sup>\u00ae<\/sup> \u2013 a patient's perspective"],"prefix":"10.1111","volume":"58","author":[{"given":"M.","family":"Schaller","sequence":"first","affiliation":[{"name":"Department of Dermatology Eberhard\u2010Karls University T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Braunsdorf","sequence":"additional","affiliation":[{"name":"Department of Dermatology Eberhard\u2010Karls University T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Mail\u00e4nder\u2010Sanchez","sequence":"additional","affiliation":[{"name":"Department of Dermatology Eberhard\u2010Karls University T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"J\u00e4ckel","sequence":"additional","affiliation":[{"name":"Medical Department Galderma Laboratorium GmbH D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Medical Department Galderma Laboratorium GmbH D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Borelli","sequence":"additional","affiliation":[{"name":"Department of Dermatology Eberhard\u2010Karls University T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,9,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp0804878"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.104794"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.107754"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.142.10.1279"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2010.07499_supp.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13358"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2004.00988.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/13693780802577892"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546630500375965"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fmyc.12371","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.12371","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T00:07:03Z","timestamp":1696205223000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/myc.12371"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,7]]},"references-count":9,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["10.1111\/myc.12371"],"URL":"https:\/\/doi.org\/10.1111\/myc.12371","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,7]]}}}