{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T05:38:53Z","timestamp":1791005933543,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,11,2]],"date-time":"2015-11-02T00:00:00Z","timestamp":1446422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The role of total and specific IgE in monitoring treatment responses in allergic bronchopulmonary aspergillosis (<jats:styled-content style=\"fixed-case\">ABPA<\/jats:styled-content>) remains poorly studied. Here in, we evaluate the utility of total and <jats:italic>Aspergillus fumigatus<\/jats:italic> specific IgE in the follow\u2010up of <jats:styled-content style=\"fixed-case\">ABPA<\/jats:styled-content>. Eighty\u2010one consecutive treatment\u2010na\u00efve patients of <jats:styled-content style=\"fixed-case\">ABPA<\/jats:styled-content> (acute stage) with pulmonary infiltrates and bronchiectasis underwent measurement of total and <jats:italic>A. fumigatus<\/jats:italic> specific IgE at baseline, after 8 weeks of glucocorticoid therapy, and during exacerbations. There was clinical and radiological improvement after treatment with median decline of total IgE by 51.9%. The total IgE declined by at least 35%, 25% and 20% in 69 (85.2%), 76 (93.6%) and 78 (96.3%) patients, respectively. On the other hand, the <jats:italic>A. fumigatus<\/jats:italic> specific IgE increased in 42 (51.9%) subjects, and the mean increase was 1.4%, after 8 weeks. Among 13 patients with exacerbation, 12 (92.3%) had a rise of total IgE by &gt;50%. The <jats:italic>A. fumigatus<\/jats:italic> specific IgE increased in only five (38.5%) subjects during exacerbation. Thus, the total IgE is a useful test in monitoring treatment responses in <jats:styled-content style=\"fixed-case\">ABPA<\/jats:styled-content> while <jats:italic>A. fumigatus<\/jats:italic> specific IgE has limited utility.<\/jats:p>","DOI":"10.1111\/myc.12423","type":"journal-article","created":{"date-parts":[[2015,11,2]],"date-time":"2015-11-02T12:34:48Z","timestamp":1446467688000},"page":"1-6","source":"Crossref","is-referenced-by-count":62,"title":["Utility of IgE (total and <i>Aspergillus fumigatus<\/i> specific) in monitoring for response and exacerbations in allergic bronchopulmonary aspergillosis"],"prefix":"10.1111","volume":"59","author":[{"given":"Ritesh","family":"Agarwal","sequence":"first","affiliation":[{"name":"Department of Pulmonary Medicine Department of Medical Microbiology Postgraduate Institute of Medical Education and Research (PGIMER) Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashutosh N.","family":"Aggarwal","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Department of Medical Microbiology Postgraduate Institute of Medical Education and Research (PGIMER) Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inderpaul S.","family":"Sehgal","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Department of Medical Microbiology Postgraduate Institute of Medical Education and Research (PGIMER) Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahajal","family":"Dhooria","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Department of Medical Microbiology Postgraduate Institute of Medical Education and Research (PGIMER) Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Digambar","family":"Behera","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Department of 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