{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:13:17Z","timestamp":1792181597021,"version":"4.4.0"},"reference-count":31,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,11,13]],"date-time":"2015-11-13T00:00:00Z","timestamp":1447372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Invasive mucormycosis is an uncommon but increasing life\u2010threatening fungal infection. The present study investigated clinical characteristics and mortality among patients diagnosed as invasive mucormycosis infection. We retrospectively reviewed a total of 24 histologically proven cases of invasive mucormycosis at two tertiary care referral hospitals between November 2005 and February 2014. Overall survival was 50% (<jats:italic>n<\/jats:italic>\u00a0=\u00a012). The time between onset of symptom and diagnostic procedure proved to be associated with mortality (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.009). In addition, preexisting renal failure and thrombocytopenia demonstrated trends toward a poor outcome in our study (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.089 and 0.065, respectively). On multivariate regression analysis, delayed diagnostic procedure (more than 16\u00a0days after the onset of symptoms) was an independent predictor of mortality (OR=\u00a012.34, 95% CI, 1.43\u201310.64; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.022). Mucormycosis is a destructive fungal infection that is associated with high mortality rates, ranging from 40% to 100% depending on the form of disease. When a clinician suspects invasive mucormycosis infection, an early diagnostic procedure performed within 16\u00a0days from the onset of symptom and early initiation of antifungal therapy will lead to successful management of this highly fatal disease.<\/jats:p>","DOI":"10.1111\/myc.12428","type":"journal-article","created":{"date-parts":[[2015,11,13]],"date-time":"2015-11-13T07:35:16Z","timestamp":1447400116000},"page":"746-752","source":"Crossref","is-referenced-by-count":42,"title":["Delaying diagnostic procedure significantly increases mortality in patients with invasive mucormycosis"],"prefix":"10.1111","volume":"58","author":[{"given":"Su Jin","family":"Jeong","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases Department of Internal Medicine Gangnam Severance Hospital Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Un","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Internal Medicine Gangnam Severance Hospital Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Goo","family":"Song","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Internal Medicine Gangnam Severance Hospital Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoung Hwa","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Internal Medicine Gangnam Severance Hospital Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Joo","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Internal Medicine Gangnam Severance Hospital Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/590004"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.13.78"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.18.3.556-569.2005"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0b013e3283165fd1"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2012.065110"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12371"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ571"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.3947\/ic.2013.45.3.292"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1086\/588660"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.5858\/2001-125-0375-HFOZ"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-9473(98)00096-6"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir868"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-03-316430"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1086\/428780"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1086\/432579"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1179\/joc.2009.21.3.322"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428190310001653691"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.10.3343-3344.2003"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01496.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181dde8fc"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis195"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1086\/521245"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1509.090334"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12234"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.53.1366"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2014.10.019"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1086\/512812"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit094"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.14.23"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00637-14"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12245"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fmyc.12428","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.12428","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T19:27:06Z","timestamp":1696188426000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/myc.12428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,13]]},"references-count":31,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.1111\/myc.12428"],"URL":"https:\/\/doi.org\/10.1111\/myc.12428","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,13]]}}}