{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T14:00:54Z","timestamp":1781272854067,"version":"3.54.1"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,11,18]],"date-time":"2015-11-18T00:00:00Z","timestamp":1447804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Madeleine Schickedanz KinderKrebs Stiftung"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Haematopoietic stem cell transplant (<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>) recipients are at high risk for mucormycosis, which has a mortality of up to 90%. The adoptive transfer of Natural killer (<jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content>) cells is a promising therapeutic option in order to improve the reconstitution of host immunity after <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> and to directly combat the fungal pathogen. As a number of fungal pathogens have developed strategies to evade the innate immune system, we investigated the interaction of human <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content> cells with various clinical isolates of different species of mucormycetes. Our results show that human <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20102 prestimulated <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content> cells damaged all mucormycetes tested. The extent of the damage depended, at least in part, on the growth curve characteristics of the individual fungal isolate. All isolates decreased the secretion of interferon\u2010\u03b3 by <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content> cells to a similar extent. Our data suggest that <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content> cells damage a wide spectrum of mucormycetes, but that the antifungal effect is higher if <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content> cells are administered at an early time point of infection.<\/jats:p>","DOI":"10.1111\/myc.12431","type":"journal-article","created":{"date-parts":[[2015,11,18]],"date-time":"2015-11-18T11:06:42Z","timestamp":1447844802000},"page":"34-38","source":"Crossref","is-referenced-by-count":43,"title":["Natural killer cell\u2010mediated damage of clinical isolates of mucormycetes"],"prefix":"10.1111","volume":"59","author":[{"given":"Stanislaw","family":"Schmidt","sequence":"first","affiliation":[{"name":"Division of Pediatric Hematology and Oncology Hospital for Children and Adolescents Johann Wolfgang Goethe\u2010University Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Schneider","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology and Oncology Hospital for Children and Adolescents Johann Wolfgang Goethe\u2010University Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asuman","family":"Demir","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology and Oncology Hospital for Children and Adolescents Johann Wolfgang Goethe\u2010University Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia","family":"Lass\u2010Fl\u00f6rl","sequence":"additional","affiliation":[{"name":"Division of Hygiene and Medical Microbiology Innsbruck Medical University Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Lehrnbecher","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology and Oncology Hospital for Children and Adolescents Johann Wolfgang Goethe\u2010University Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2009.02978.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2013.00017"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.5.3357"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit574"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiq062"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2012.10.013"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1003593"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2009.01.019"},{"key":"e_1_2_6_10_1","first-page":"12","article-title":"Natural 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