{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:32:12Z","timestamp":1761863532482},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T00:00:00Z","timestamp":1449014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Invasive pulmonary aspergillosis (<jats:styled-content style=\"fixed-case\">IPA<\/jats:styled-content>) is a life\u2010threatening infection mainly affecting immunocompromised patients. Early diagnosis is critical, but the diagnostic gold standard (histopathology and culture) is time consuming and cannot offer early confirmation of <jats:styled-content style=\"fixed-case\">IPA<\/jats:styled-content>. Fungal biomarkers like galactomannan (<jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content>) are a promising extension to the diagnostic repertoire. However, it still remains under discussion if biomarker analysis from the site of the infection is superior to testing blood samples. We retrospectively evaluated the diagnostic performance of concurrent serum <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content> and bronchoalveolar lavage (<jats:styled-content style=\"fixed-case\">BAL<\/jats:styled-content>) <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content> (obtained within 24 h) of immunocompromised patients at high risk of <jats:styled-content style=\"fixed-case\">IPA<\/jats:styled-content>. Twenty\u2010six proven\/probable patients and eight patients with no <jats:styled-content style=\"fixed-case\">IPA<\/jats:styled-content> according to the <jats:styled-content style=\"fixed-case\">EORTC<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">MSG<\/jats:styled-content> 2008 criteria were included in this study. Sensitivity, specificity, positive predictive value, negative predictive value and diagnostic odds ratio were for <jats:styled-content style=\"fixed-case\">BAL GM<\/jats:styled-content>: 85%, 88%, 96%, 64% and 38.5, and for serum <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content>: 23%, 88%, 88%, 26% and 2.1 respectively. <jats:styled-content style=\"fixed-case\">BAL GM<\/jats:styled-content> proved to be significantly more sensitive for the detection of <jats:styled-content style=\"fixed-case\">IPA<\/jats:styled-content> compared to same\u2010day serum <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content> in patients at high risk of <jats:styled-content style=\"fixed-case\">IPA<\/jats:styled-content> (<jats:italic>P<\/jats:italic> &lt; 0.0001). Our data show that <jats:styled-content style=\"fixed-case\">BAL GM<\/jats:styled-content> testing is significantly superior to serum <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content> implying that diagnostic efforts should focus on specimens from the site of infection.<\/jats:p>","DOI":"10.1111\/myc.12434","type":"journal-article","created":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T07:53:43Z","timestamp":1449042823000},"page":"80-85","source":"Crossref","is-referenced-by-count":20,"title":["Direct comparison of galactomannan performance in concurrent serum and bronchoalveolar lavage samples in immunocompromised patients at risk for invasive pulmonary aspergillosis"],"prefix":"10.1111","volume":"59","author":[{"given":"Tobias","family":"Boch","sequence":"first","affiliation":[{"name":"Department of Hematology and Oncology Mannheim University Hospital University of Heidelberg Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dieter","family":"Buchheidt","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Mannheim University Hospital University of Heidelberg Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgit","family":"Spiess","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Mannheim University Hospital University of Heidelberg Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Miethke","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology and Hygiene Mannheim University Hospital University of Heidelberg Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolf\u2010Karsten","family":"Hofmann","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Mannheim University Hospital University of 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