{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T12:55:23Z","timestamp":1783342523179,"version":"3.54.6"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,12,22]],"date-time":"2015-12-22T00:00:00Z","timestamp":1450742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004569","name":"Ministerstwo Nauki i Szkolnictwa Wy\u017cszego","doi-asserted-by":"publisher","award":["8636\/E342\/R\/2014"],"award-info":[{"award-number":["8636\/E342\/R\/2014"]}],"id":[{"id":"10.13039\/501100004569","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Severe skin diseases and systemic fungaemia are caused by <jats:italic>Malassezia pachydermatis<\/jats:italic> and <jats:italic>Candida albicans<\/jats:italic> respectively. Antifungal therapies are less effective because of chronic character of infections and high percentage of relapses. Therefore, there is a great need to develop new strategies of antifungal therapies. We previously found that oxythiamine decreases proliferation of yeast (<jats:italic>Saccharomyces cerevisiae<\/jats:italic>), therefore we suggest that thiamine antivitamins can be considered as antifungal agents. The aim of this study was the comparison of thiamine antivitamins (oxythiamine, amprolium, thiochrome, tetrahydrothiamine and tetrahydrooxythiamine) inhibitory effect on the growth rate and energetic metabolism efficiency in non\u2010pathogenic <jats:italic>S. cerevisiae<\/jats:italic> and two potentially pathogenic species <jats:italic>M. pachydermatis<\/jats:italic> and <jats:italic>C. albicans<\/jats:italic>. Investigated species were cultured on a Sabouraud medium supplemented with trace elements in the presence (40 mg l<jats:sup>\u22121<\/jats:sup>) or absence of each tested antivitamins to estimate their influence on growth rate, enzyme activity and kinetic parameters of pyruvate decarboxylase and malate dehydrogenase of each tested species. Oxythiamine was the only antivitamin with antifungal potential. <jats:italic>M. pachydermatis<\/jats:italic> and <jats:italic>S. cerevisiae<\/jats:italic> were the most sensitive, whereas <jats:italic>C. albicans<\/jats:italic> was the least sensitive to oxythiamine action. Oxythiamine can be considered as supportive agent in superficial mycoses treatment, especially those caused by species from the genus <jats:italic>Malassezia<\/jats:italic>.<\/jats:p>","DOI":"10.1111\/myc.12441","type":"journal-article","created":{"date-parts":[[2015,12,22]],"date-time":"2015-12-22T11:06:26Z","timestamp":1450782386000},"page":"108-116","source":"Crossref","is-referenced-by-count":11,"title":["Thiamine antivitamins \u2013 an opportunity of therapy of fungal infections caused by <i><scp>M<\/scp>alassezia pachydermatis<\/i> and <i><scp>C<\/scp>andida albicans<\/i>"],"prefix":"10.1111","volume":"59","author":[{"given":"Magdalena","family":"Siemieniuk","sequence":"first","affiliation":[{"name":"Departament of Cytobiochemistry Institute of Biology University of Bialystok Bialystok Poland"},{"name":"Laboratory of Tissue Culture Institute of Biology University of Bialystok Bialystok Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urszula","family":"Czyzewska","sequence":"additional","affiliation":[{"name":"Departament of Cytobiochemistry Institute of Biology University of Bialystok Bialystok Poland"},{"name":"Laboratory of Tissue Culture Institute of Biology University of Bialystok Bialystok Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Slawomir","family":"Strumilo","sequence":"additional","affiliation":[{"name":"Departament of Cytobiochemistry Institute of Biology University of Bialystok Bialystok Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Tylicki","sequence":"additional","affiliation":[{"name":"Departament of Cytobiochemistry Institute of Biology University of Bialystok Bialystok Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2008.01606.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2009.12.005"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2012.761134"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2007.140087"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.045054-0"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(10)70218-8"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2003.12.034"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00021-11"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.12.022"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2013.01.012"},{"key":"e_1_2_7_12_1","first-page":"323","article-title":"Malassezia infections","volume":"11","author":"Dworecka\u2010Kaszak B","year":"2004","journal-title":"Mikol Lek"},{"key":"e_1_2_7_13_1","first-page":"145","article-title":"Prevalance of Malassezia pachydermatis and other organisms in healthy and infected dog ears","volume":"57","author":"Kumar A","year":"2002","journal-title":"Isr J Vet Med"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2009.01814.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mmcr.2014.04.004"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2012.04.005"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.3402\/jom.v5i0.22434"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myt004"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2013.11.008"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12380"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S40160"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.400"},{"key":"e_1_2_7_23_1","first-page":"605","article-title":"Ketoconazole associated hepatoxicity: a systematic review and meta\u2010analysis","volume":"26","author":"Yan JY","year":"2013","journal-title":"Biomed Environ Sci"},{"key":"e_1_2_7_24_1","first-page":"769","article-title":"The effect of thiamine and oxythiamine on the rate of growth of Saccharomyces cerevisiae in vitro culture","volume":"6","author":"Tylicki A","year":"2001","journal-title":"Cell Mol Biol Lett"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/jobm.200310290"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.12512"},{"key":"e_1_2_7_27_1","first-page":"49","article-title":"Review of the biochemistry, metabolism and clinical benefits of thiamin(e) and its derivatives","volume":"3","author":"Lonsdale DA","year":"2006","journal-title":"eCAM"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2009.07018.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.7.41"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-386479-6.00004-4"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2009.07019.x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/35083594"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2005.00676.x"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1128\/EC.3.5.1076-1087.2004"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1139\/w05-072"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1128\/jb.173.8.2716-2719.1991"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2007.11.098"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(68)90225-0"},{"key":"e_1_2_7_40_1","first-page":"1083","article-title":"Interaction of thiamin analogues with yeast thiamine pyrophosphokinase","volume":"3","author":"Ostrovsky YM","year":"1977","journal-title":"Bioorg Khim"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1970.tb00260.x"},{"key":"e_1_2_7_42_1","first-page":"133","article-title":"What's new about Malassezia pachydermatis?","volume":"6","author":"Dworecka\u2010Kaszak B","year":"1999","journal-title":"Mikol Lek"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13105-012-0146-2"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2003.10.019"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.65.1659"},{"key":"e_1_2_7_46_1","first-page":"69","article-title":"Antifungal efficacy of oxythiamine \u2013 antivitamin derivative of vitamin B1","author":"Ziolkowska G","year":"2006","journal-title":"Annales Universitatis Marie Curie\u2010Sklodowska Lublin\u2010Polonia"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1993.tb05668.x"},{"key":"e_1_2_7_48_1","first-page":"4242","article-title":"Oxythiamine and dehydroepiandrosterone inhibit the nonoxidative synthesis of ribose and tumor cell proliferation","volume":"57","author":"Boros LG","year":"1997","journal-title":"Cancer Res"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-015-2336-z"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fmyc.12441","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.12441","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T11:33:30Z","timestamp":1696246410000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/myc.12441"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,22]]},"references-count":48,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.1111\/myc.12441"],"URL":"https:\/\/doi.org\/10.1111\/myc.12441","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,22]]}}}