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However, important differences exist between children and adults regarding epidemiology, underlying disease, and comorbidities, and the value of diagnostic tools to detect <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content> may also differ between these patient populations. Imaging studies are important to detect <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content> early, but typical findings of <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content> in chest computed tomography of adults are not detected in the majority of children. Whereas the value of the serum marker galactomannan seems to be comparable in children and adults, data on the performance of beta\u2010<jats:sc>d<\/jats:sc>\u2010glucan in children are too limited for firm conclusions. <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>\u2010based assays are a promising diagnostic approach to rapidly and reliably detect and identify <jats:italic>Aspergillus<\/jats:italic> species in various clinical samples. However, as the majority of data on <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>\u2010based approaches has been obtained in adult patients, the value of this method in paediatric patients has not been defined to date. The present review focuses on studies of <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>\u2010based methods to diagnose <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content> in immunocompromised paediatric patients.<\/jats:p>","DOI":"10.1111\/myc.12443","type":"journal-article","created":{"date-parts":[[2015,12,14]],"date-time":"2015-12-14T09:58:49Z","timestamp":1450087129000},"page":"67-74","source":"Crossref","is-referenced-by-count":16,"title":["Biomarker\u2010based diagnostic work\u2010up of invasive pulmonary aspergillosis in immunocompromised paediatric patients \u2013 is <i>Aspergillus<\/i> PCR appropriate?"],"prefix":"10.1111","volume":"59","author":[{"given":"Dieter","family":"Buchheidt","sequence":"first","affiliation":[{"name":"Department of Hematology and Oncology Mannheim University Hospital University of Heidelberg Mannheim 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