{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T11:05:33Z","timestamp":1774436733403,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,12,29]],"date-time":"2015-12-29T00:00:00Z","timestamp":1451347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Serbian Ministry of Education and Science","award":["III 175034"],"award-info":[{"award-number":["III 175034"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Despite the increasing of onychomycosis caused by <jats:italic>Candida<\/jats:italic> spp., in referent literature, there is still data insufficiency about this nail infection. The objectives of this retrospective study were to determine epidemiological characteristics of <jats:italic>Candida<\/jats:italic> onychomycosis, the antifungal susceptibility of isolated species <jats:italic>in vitro<\/jats:italic>, and to compare the results of antifungal susceptibility testing with conducted treatment in period from 2011 to the end of March 2015. Out of 761 patients who were underwent clinical and mycological examinations, 137 had <jats:italic>Candida<\/jats:italic> species isolated from nails. The dominant species was <jats:italic>Candida albicans<\/jats:italic> (<jats:italic>C. albicans<\/jats:italic>) (36.59%) followed by <jats:italic>C. parapsilosis<\/jats:italic> (23.78%), <jats:italic>C. krusei<\/jats:italic> (9.76%), and <jats:italic>C. guilliermondii<\/jats:italic> (6.71%). Antifungal susceptibility <jats:italic>in vitro<\/jats:italic> testing showed good susceptibility to antimycotics, except <jats:italic>C. krusei<\/jats:italic>, which was resistance to fluconazole (<jats:styled-content style=\"fixed-case\">FCZ<\/jats:styled-content>) and isolates of <jats:italic>C. tropicalis<\/jats:italic> and <jats:italic>C. glabrata<\/jats:italic> which were dose dependent to itraconazole (<jats:styled-content style=\"fixed-case\">ITZ<\/jats:styled-content>) and fluconazole. Evaluation of medical histories determined that combined therapy, which included pulsed systemic regimen of <jats:styled-content style=\"fixed-case\">ITZ<\/jats:styled-content> with topical application of clotrimazole, had better clinical outcomes regarding the proscribed only topical application of clotrimazole. Multidisciplinary approach of dermatologists and mycologists is required in solving the problem of onychomycosis, which is the dominant nail disease.<\/jats:p>","DOI":"10.1111\/myc.12448","type":"journal-article","created":{"date-parts":[[2015,12,29]],"date-time":"2015-12-29T11:38:49Z","timestamp":1451389129000},"page":"167-172","source":"Crossref","is-referenced-by-count":36,"title":["The prevalence of <i>Candida<\/i> onychomycosis in Southeastern Serbia from 2011 to 2015"],"prefix":"10.1111","volume":"59","author":[{"given":"Suzana","family":"Ota\u0161evi\u0107","sequence":"first","affiliation":[{"name":"Center of Microbiology and Parasitology Public Health Institute Ni\u0161 Ni\u0161 Serbia"},{"name":"Department of Microbiology and Immunology Faculty of Medicine University of Ni\u0161 Ni\u0161 Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"Barac","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology Faculty of Medicine University of Belgrade Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Pekmezovic","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology Faculty of Medicine University of Belgrade Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sinisa","family":"Tasic","sequence":"additional","affiliation":[{"name":"Clinic for skin and veneral diseases Clinical Center of Vojvodina Novi Sad Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"Ignjatovi\u0107","sequence":"additional","affiliation":[{"name":"Center of Microbiology and Parasitology Public Health Institute Ni\u0161 Ni\u0161 Serbia"},{"name":"Department of Medical Statistics Faculty of Medicine University of Ni\u0161 Ni\u0161 Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Mom\u010dilovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology Faculty of Medicine University of Ni\u0161 Ni\u0161 Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Predrag","family":"Stojanovi\u0107","sequence":"additional","affiliation":[{"name":"Center of Microbiology and Parasitology Public Health Institute Ni\u0161 Ni\u0161 Serbia"},{"name":"Department of Microbiology and Immunology Faculty of Medicine University of Ni\u0161 Ni\u0161 Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Arsic Arsenijevic","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology Faculty of Medicine University of Belgrade Belgrade Serbia"},{"name":"National Medical Mycology Reference Laboratory Department of Microbiology and Immunology Faculty of Medicine University of Belgrade Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roderick","family":"Hay","sequence":"additional","affiliation":[{"name":"Department of Dermatology Skin Infection Clinic Kings College Hospital NHS Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,12,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00013-08"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp0804878"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.09.730"},{"key":"e_1_2_7_5_1","first-page":"s96","article-title":"Onchomycosis: an overview","volume":"12","author":"Elewski BE","year":"2013","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_7_6_1","first-page":"45","article-title":"Etiopathogenesis, clinical picture and diagnosis of onychomycoses","volume":"54","author":"Tasi\u0107 S","year":"2001","journal-title":"Med Pregl"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02056-12"},{"key":"e_1_2_7_8_1","first-page":"379725","article-title":"The effect of Q\u2010switched Nd:YAG 1064 nm\/532 nm laser in the treatment of onychomycosis in vivo","volume":"2013","author":"Kalokasidis K","year":"2013","journal-title":"Dermatol Res Pract"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.18.1.30-43.2005"},{"key":"e_1_2_7_10_1","first-page":"106","volume-title":"Cutaneous fungal infections","author":"Cohen JL","year":"1992"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.11.3.415"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05728.x"},{"key":"e_1_2_7_13_1","unstructured":"Ota\u0161evicS.Superficijalne mikoze u svetu i kod nas\u2010epidemiolo\u0161ki aspekt. 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