{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T03:42:25Z","timestamp":1784432545840,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,1,13]],"date-time":"2016-01-13T00:00:00Z","timestamp":1452643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Palacky University Olomouc","award":["IGA_LF_2015_035"],"award-info":[{"award-number":["IGA_LF_2015_035"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Clinical yeast isolates belonging to <jats:italic>Candida pelliculosa, Candida utilis<\/jats:italic> and <jats:italic>Candida fabianii<\/jats:italic> are difficult to distinguish in a routine mycology laboratory using common biochemical tests. The aims of this study were to determine the prevalence of <jats:italic>C. pelliculosa<\/jats:italic>,<jats:italic> C. utilis<\/jats:italic> and <jats:italic>C. fabianii<\/jats:italic> in clinical samples and to compare their minimum inhibitory concentrations (<jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content>s) to systemic antifungals. Two hundred and forty\u2010eight clinical yeast isolates obtained from eight large hospitals in the Czech Republic were included in this study. Identification was performed biochemically using <jats:styled-content style=\"fixed-case\">ID<\/jats:styled-content> 32C kit and by <jats:styled-content style=\"fixed-case\">MALDI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">TOF MS<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content>s were determined using colorimetric broth dilution Sensititre YeastOne panels. From a total number of 248 isolates, 175 were identified as <jats:italic>C. pelliculosa<\/jats:italic> and 73 as <jats:italic>C. utilis<\/jats:italic> using the biochemical kit. In contrast, <jats:styled-content style=\"fixed-case\">MALDI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">TOF MS<\/jats:styled-content> identified 222 isolates as <jats:italic>C. fabianii<\/jats:italic>, 20 as <jats:italic>C. pelliculosa<\/jats:italic> and 6 as <jats:italic>C. utilis<\/jats:italic>. The highest mean <jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content>s were found in <jats:italic>C. fabianii<\/jats:italic> and, regardless of the studied species, in isolates from blood cultures and central venous catheters. <jats:styled-content style=\"fixed-case\">MALDI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">TOF MS<\/jats:styled-content> revealed <jats:italic>C. fabianii<\/jats:italic> to be most prevalent in clinical samples as compared with the other studied species. Higher <jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content> values in <jats:italic>C. fabianii<\/jats:italic> support the importance of correct identification of this species.<\/jats:p>","DOI":"10.1111\/myc.12454","type":"journal-article","created":{"date-parts":[[2016,1,14]],"date-time":"2016-01-14T03:21:41Z","timestamp":1452741701000},"page":"241-246","source":"Crossref","is-referenced-by-count":19,"title":["High frequency of <i><scp>C<\/scp>andida fabianii<\/i> among clinical isolates biochemically identified as <i><scp>C<\/scp>andida pelliculosa<\/i> and <i><scp>C<\/scp>andida utilis<\/i>"],"prefix":"10.1111","volume":"59","author":[{"given":"L.","family":"Svobodova","sequence":"first","affiliation":[{"name":"Department of Microbiology Faculty of Medicine and Dentistry Palacky University Olomouc and University Hospital Olomouc Olomouc Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Bednarova","sequence":"additional","affiliation":[{"name":"Research &amp; Development Department GeneProof a.s. Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Ruzicka","sequence":"additional","affiliation":[{"name":"Department of Microbiology Faculty of Medicine Masaryk University Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Chrenkova","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology 2nd Faculty of Medicine Charles University in Prague and Motol University Hospital Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Dobias","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Mycology Public Health Institute Ostrava Ostrava Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Mallatova","sequence":"additional","affiliation":[{"name":"Laboratory of Parasitology and Mycology Ceske Budejovice Hospital Ceske Budejovice Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Buchta","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology Faculty of Medicine and University Hospital Charles University Hradec Kralove Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Kocmanova","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology University Hospital Brno Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Olisarova","sequence":"additional","affiliation":[{"name":"Mycology Laboratory Clinical Microbiology and ATB Centre Institute of Medical Biochemistry and Laboratory Diagnostics of the General University Hospital and of the First Faculty of Medicine of Charles University in Prague Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Stromerova","sequence":"additional","affiliation":[{"name":"State Veterinary Institute Olomouc Olomouc Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Thongsri","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Immunology Research Unit (CMIRU) Department of Medical Technology Faculty of Allied Health Science Naresuan University Phitsanulok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Hamal","sequence":"additional","affiliation":[{"name":"Department of Microbiology Faculty of Medicine and Dentistry Palacky University Olomouc and University Hospital Olomouc Olomouc Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,1,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(95)00010-0"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/529435"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhin.2001.1151"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23466"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1754-4505.2000.tb00015.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2008.01574.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(03)00415-2"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dki218"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2003.00719.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msr121"},{"key":"e_1_2_7_12_1","volume-title":"Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts; Approved Standard\u2010Third Edition","author":"National Committee for Clinical Laboratory Standards","year":"2008"},{"key":"e_1_2_7_13_1","volume-title":"The Yeasts: A Taxonomic Study","author":"Kurtzman CP","year":"1998"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11274-014-1602-7"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fm.2009.12.009"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/161.5.1040"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/13693780500160793"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2006.01240.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/13693780802078180"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3181c4f7d9"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.3109\/13693786.2011.587455"},{"key":"e_1_2_7_22_1","first-page":"922","article-title":"Catheter\u2010related bloodstream infection by Lindnera fabianii in a neutropenic patient","volume":"62","author":"Yun JW","year":"2013","journal-title":"J Clin Microbiol"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-6-77"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fmyc.12454","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.12454","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T05:35:13Z","timestamp":1696224913000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/myc.12454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,13]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.1111\/myc.12454"],"URL":"https:\/\/doi.org\/10.1111\/myc.12454","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,13]]}}}