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In fact, three out of every four women will experience at least one occasion of<jats:styled-content style=\"fixed-case\">VVC<\/jats:styled-content>during some point in their lives. Although uncomplicated<jats:styled-content style=\"fixed-case\">VVC<\/jats:styled-content>is relatively harmless, the complicated<jats:styled-content style=\"fixed-case\">VVC<\/jats:styled-content>such as recurrent attack often creates restlessness and depression in the patients, thus greatly affects their quality of life. Managements of<jats:styled-content style=\"fixed-case\">VVC<\/jats:styled-content>are usually associated with the use of antimycotic suppositories, topical cream or oral agents. These antimycotic agents are either available over\u2010the\u2010counter or prescribed by the clinicians. In recent decades, the rise of clinical challenges such as the increased prevalence of resistant<jats:italic>Candida<\/jats:italic>strains, recurrent<jats:styled-content style=\"fixed-case\">VVC<\/jats:styled-content>infection and adverse effects of multidrug interactions have necessitated the development of novel therapeutic or prophylactic options to combat the complicated<jats:styled-content style=\"fixed-case\">VVC<\/jats:styled-content>in the future. In this review, we discuss the current antimycotic treatments available for<jats:italic>Candida<\/jats:italic>vaginitis and the problems that exist in these seemingly effective treatments. Besides, we attempt to contemplate some of the future and prospective strategies surrounding the development of alternative therapeutic and prophylactic options in treating and preventing complicated<jats:styled-content style=\"fixed-case\">VVC<\/jats:styled-content>respectively.<\/jats:p>","DOI":"10.1111\/myc.12455","type":"journal-article","created":{"date-parts":[[2016,1,14]],"date-time":"2016-01-14T08:53:17Z","timestamp":1452761597000},"page":"262-273","source":"Crossref","is-referenced-by-count":44,"title":["Vulvovaginal candidosis: contemporary challenges and the future of prophylactic and therapeutic approaches"],"prefix":"10.1111","volume":"59","author":[{"given":"Shu Yih","family":"Chew","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology and Parasitology Faculty of Medicine and Health Sciences Universiti Putra Malaysia 43300 Serdang Selangor Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie Thian Lung","family":"Than","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Parasitology Faculty of Medicine and Health Sciences Universiti Putra Malaysia 43300 Serdang Selangor Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,1,13]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(98)80001-X"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2006.00450.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(98)00264-6"},{"key":"e_1_2_5_5_1","first-page":"190","article-title":"Recurrent vulvovaginitis: diagnostic assessment and therapeutic management","volume":"99","author":"Ramirez\u2010Santos A","year":"2008","journal-title":"Actas Dermosifiliogr"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007435-200004000-00009"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60917-9"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/jinf.2000.0723"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2005.03.005"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-2-1"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-965681"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12292"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2222-1808(12)60011-5"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002512-200016050-00003"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(01)01759-8"},{"key":"e_1_2_5_16_1","volume-title":"The Fungus Fighters: Two Women Scientists and Their Discovery","author":"Baldwin RS","year":"1981"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/44.3.397"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6976.2011.00278.x"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00029-06"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4914(02)02280-3"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.03.034"},{"key":"e_1_2_5_22_1","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1128\/CMR.1.2.187","article-title":"Overview of medically important antifungal azole derivatives","volume":"12","author":"Fromtling RA","year":"1988","journal-title":"Clin Microbiol Rev"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(08)81495-8"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2660475"},{"key":"e_1_2_5_25_1","first-page":"1","article-title":"Sexually Transmitted Diseases Treatment Guidelines, 2015","volume":"64","author":"Workowski KA","year":"2015","journal-title":"MMWR Recomm Rep"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1701-2163(15)30316-9"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjid.2013.02.001"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(08)81259-5"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)91490-0"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.1992.tb00887.x"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja01573a087"},{"key":"e_1_2_5_32_1","first-page":"305","article-title":"Studies on fluorinated pyrimidines. 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