{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T16:32:00Z","timestamp":1770136320120,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,2,9]],"date-time":"2016-02-09T00:00:00Z","timestamp":1454976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004963","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["HEALTH\u2010F3\u20102013\u2010601963"],"award-info":[{"award-number":["HEALTH\u2010F3\u20102013\u2010601963"]}],"id":[{"id":"10.13039\/501100004963","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:italic>Candida kefyr<\/jats:italic> is an emerging pathogen able to cause disseminated infection, especially in immunocompromised patients. Although guidelines for the treatment of invasive candidiasis have been published, no specific recommendations against <jats:italic>C. kefyr<\/jats:italic> are available. We determine the <jats:italic>in vitro<\/jats:italic> killing activity of amphotericin B (<jats:styled-content style=\"fixed-case\">AMB<\/jats:styled-content>), fluconazole (<jats:styled-content style=\"fixed-case\">FLC<\/jats:styled-content>) and caspofungin (<jats:styled-content style=\"fixed-case\">CFG<\/jats:styled-content>) as well as their efficacy in a murine model of systemic infection by two <jats:italic>C. kefyr<\/jats:italic> strains. Time\u2010kill curves of <jats:styled-content style=\"fixed-case\">AMB<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> FLC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CFG<\/jats:styled-content> were determined in final volumes of 10 ml containing the assayed drugs ranged from 0.03 to 32 \u03bcg ml<jats:sup>\u22121<\/jats:sup> at different time points and efficacy of the drugs was evaluated in a systemic model of candidiasis, conducted in immunosuppressed mice, through survival, (1\u21923)\u2010\u03b2\u2010D\u2010glucan levels in serum and fungal load in kidneys. <jats:styled-content style=\"fixed-case\">AMB<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CFG<\/jats:styled-content> showed fungicidal and <jats:styled-content style=\"fixed-case\">FLC<\/jats:styled-content> fungistatic activity against both isolates. The three drugs were able to reduce fungal burden in kidneys and (1\u21923)\u2010\u03b2\u2010D\u2010glucan concentration in serum of infected mice, with <jats:styled-content style=\"fixed-case\">CFG<\/jats:styled-content> showing the highest efficacy, followed by <jats:styled-content style=\"fixed-case\">FLC<\/jats:styled-content>. In conclusion, <jats:styled-content style=\"fixed-case\">CFG<\/jats:styled-content> showed efficacy over <jats:styled-content style=\"fixed-case\">AMB<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">FLC<\/jats:styled-content> against the systemic candidiasis by <jats:italic>C. kefyr<\/jats:italic>. The established epidemiological cut\u2010off for anidulafungin seems the best indicator of outcome for echinocandins.<\/jats:p>","DOI":"10.1111\/myc.12468","type":"journal-article","created":{"date-parts":[[2016,2,9]],"date-time":"2016-02-09T08:55:09Z","timestamp":1455008109000},"page":"253-258","source":"Crossref","is-referenced-by-count":5,"title":["Antifungal therapies in murine infections by <i>Candida kefyr<\/i>"],"prefix":"10.1111","volume":"59","author":[{"given":"Marta","family":"Sanchis","sequence":"first","affiliation":[{"name":"Unitat de Microbiologia Facultat de Medicina i Ci\u00e8ncies de la Salut IISPV Universitat Rovira i Virgili Reus Tarragona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adela","family":"Martin\u2010Vicente","sequence":"additional","affiliation":[{"name":"Unitat de Microbiologia Facultat de Medicina i Ci\u00e8ncies de la Salut IISPV Universitat Rovira i Virgili Reus Tarragona 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