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Notably, among isolates that were primarily sensitive to fluconazole such as <jats:italic>Candida parapsilosis<\/jats:italic> and <jats:italic>Candida tropicalis<\/jats:italic> have witnessed an emerging resistance development. Also for echinocandins, the occurrence of <jats:italic>Candida<\/jats:italic> isolates with lower susceptibility to these drugs has been reported, which is possibly due to its broad clinical use. Triazole resistance among <jats:italic>Aspergillus fumigatus<\/jats:italic> and other <jats:italic>Aspergillus<\/jats:italic> species is commonly found in European and Asian countries. Specific mutations are associated with azole resistance in <jats:italic>A. fumigatus<\/jats:italic> and these mutations are now reported globally from six continents. Therefore, we highlight the need to conduct antifungal resistance surveillance studies using clinical isolates of <jats:italic>Candida<\/jats:italic> and <jats:italic>Aspergillus<\/jats:italic> in different geographical regions and monitoring of the infection rates in distinct population groups for early detection of resistance to these drugs and implementation of efficient policies for infection control and treatment.<\/jats:p>","DOI":"10.1111\/myc.12469","type":"journal-article","created":{"date-parts":[[2016,1,26]],"date-time":"2016-01-26T07:36:52Z","timestamp":1453793812000},"page":"198-219","source":"Crossref","is-referenced-by-count":162,"title":["Epidemiology and molecular mechanisms of antifungal resistance in\u00a0<i>Candida<\/i> and <i>Aspergillus<\/i>"],"prefix":"10.1111","volume":"59","author":[{"given":"Sarah Santos","family":"Gon\u00e7alves","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio Especial de Micologia, Disciplina de Infectologia, Escola Paulista de 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