{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T19:00:39Z","timestamp":1776970839153,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,2,11]],"date-time":"2016-02-11T00:00:00Z","timestamp":1455148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009754","name":"Galderma","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009754","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>As onychomycosis is unsightly, this study clinically evaluated whether the antifungal efficacy of amorolfine 5% nail lacquer (<jats:styled-content style=\"fixed-case\">NL<\/jats:styled-content>) was affected by a masking, natural\u2010coloured, cosmetic nail varnish applied 24 h later; <jats:italic>in vitro<\/jats:italic> investigations were also performed. Subjects with mild\u2010to\u2010moderate distal subungual toenail onychomycosis were randomised to receive amorolfine 5% <jats:styled-content style=\"fixed-case\">NL<\/jats:styled-content> once weekly with or without cosmetic nail varnish applied 24 h later. After 12\u2010week treatment, antifungal activity of affected toenail clippings was assessed by measurement of zones of inhibition (ZOIs) on <jats:italic>Trichophyton mentagrophytes<\/jats:italic> seeded agar plates. Mean diameters were 53.5 mm for the amorolfine 5% <jats:styled-content style=\"fixed-case\">NL<\/jats:styled-content>\u2010alone group (<jats:italic>n<\/jats:italic> = 23) and 53.6 mm for amorolfine 5% <jats:styled-content style=\"fixed-case\">NL<\/jats:styled-content> plus cosmetic nail varnish group (<jats:italic>n<\/jats:italic> = 25). Also, mycological cultures of subungual debris at week 12 were negative for all subjects in both groups. Most subjects (88%) reported that cosmetic nail varnish masked their infected toenails. Additionally, cadaver human nails coated <jats:italic>in vitro<\/jats:italic> with or without cosmetic nail varnish 10 min or 24 h post amorolfine <jats:styled-content style=\"fixed-case\">NL<\/jats:styled-content> application all gave ZOIs on <jats:italic>Trichophyton rubrum<\/jats:italic> agar plates representing potent antifungal activity. In conclusion, cosmetic nail varnish applied post amorolfine had no effect on the subungual antifungal activity of amorolfine 5% <jats:styled-content style=\"fixed-case\">NL<\/jats:styled-content> or its penetration through toenails.<\/jats:p>","DOI":"10.1111\/myc.12473","type":"journal-article","created":{"date-parts":[[2016,2,12]],"date-time":"2016-02-12T08:11:43Z","timestamp":1455264703000},"page":"319-326","source":"Crossref","is-referenced-by-count":8,"title":["Application of cosmetic nail varnish does not affect the antifungal efficacy of amorolfine 5% nail lacquer in the treatment of distal subungual toenail onychomycosis: results of a randomised active\u2010controlled study and <i>in vitro<\/i> assays"],"prefix":"10.1111","volume":"59","author":[{"given":"B.","family":"Sigurgeirsson","sequence":"first","affiliation":[{"name":"Cutis Ehf Dermatology Center K\u00f3pvogur Iceland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. A.","family":"Ghannoum","sequence":"additional","affiliation":[{"name":"Center for Medical Mycology University Hospitals of Cleveland\/Case Western Reserve University Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Osman\u2010Ponchet","sequence":"additional","affiliation":[{"name":"Galderma R &amp; D SNC Sophia Antipolis France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Kerrouche","sequence":"additional","affiliation":[{"name":"Galderma R &amp; D SNC Sophia Antipolis France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Sidou","sequence":"additional","affiliation":[{"name":"Galderma R &amp; D SNC Sophia Antipolis France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12323"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2005.01281.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(03)02117-0"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.12.019"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.09.730"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.10.4817-4819.2003"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12369"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1992.tb00270.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1994.tb06087.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1751-0759-8-15"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1993.tb02844.x"},{"key":"e_1_2_8_13_1","unstructured":"Clinical Laboratory Standards Institute.Proposed Guideline Performance Standards for Antimicrobial Disk Susceptibility Tests; Approved Standard 11th edn M02\u2010A11 2012."},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-016-0093-x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.107754"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/000155502762064665"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008986826756"},{"key":"e_1_2_8_18_1","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1684\/ejd.2013.2048","article-title":"The impact of nail disorders on quality of life","volume":"23","author":"Belyayeva E","year":"2013","journal-title":"Eur J Dermatol"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12122"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1992.tb00278.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1992.tb00277.x"},{"key":"e_1_2_8_22_1","first-page":"675","article-title":"In vitro nail penetration of tavaborole topical solution, 5%, through nail polish on ex vivo human fingernails","volume":"14","author":"Vlahovic T","year":"2015","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_8_23_1","first-page":"34","article-title":"Penetration of ((14)C)\u2010efinaconazole topical solution, 10%, does not appear to be influenced by nail polish","volume":"7","author":"Zeichner JA","year":"2014","journal-title":"J Clin Aesthet Dermatol"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fmyc.12473","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.12473","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/myc.12473","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.12473","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T09:55:16Z","timestamp":1696499716000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/myc.12473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,11]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.1111\/myc.12473"],"URL":"https:\/\/doi.org\/10.1111\/myc.12473","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,11]]}}}