{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T13:54:09Z","timestamp":1780322049121,"version":"3.54.1"},"reference-count":109,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,2,15]],"date-time":"2016-02-15T00:00:00Z","timestamp":1455494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran","award":["Nr. 2012"],"award-info":[{"award-number":["Nr. 2012"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Fungi in the order Mucorales cause acute, invasive and frequently fatal infections in susceptible patients. This study aimed to perform a systematic review of all reported mucormycosis cases during the last 25 years in Iran. After a comprehensive literature search, we identified 98 cases in Iran from 1990\u20132015. The mean patient age was 39.8 \u00b1 19.2 years. Diabetes was the most common underlying condition (47.9%), and 22.4% of the patients underwent solid organ or bone marrow transplantation. The most common clinical forms of mucormycosis were rhinocerebral (48.9%), pulmonary (9.2%) and cutaneous (9.2%). Eight cases of disseminated disease were identified. Overall mortality in the identified cases was 40.8%, with the highest mortality rate in patients diagnosed with disseminated infection (75%). The mortality rate in rhinocerebral infection patients was significantly lower (45.8%). Rhinocerebral infection was the most common clinical manifestation in diabetes patients (72.9%). Patients were diagnosed using various methods including histopathology (85.7%), microscopy (12.3%) and culture (2.0%). <jats:italic>Rhizopus<\/jats:italic> species were the most prevalent (51.7%), followed by <jats:italic>Mucor<\/jats:italic> species (17.2%). Sixty\u2010nine patients were treated with a combination of surgery and antifungal therapy (resulting survival rate, 66.7%). Owing to the high mortality rate of advanced mucormycosis, early diagnosis and treatment may significantly improve survival rates. Therefore, increased monitoring and awareness of this life\u2010threatening disease is critical.<\/jats:p>","DOI":"10.1111\/myc.12474","type":"journal-article","created":{"date-parts":[[2016,2,15]],"date-time":"2016-02-15T06:52:52Z","timestamp":1455519172000},"page":"402-415","source":"Crossref","is-referenced-by-count":90,"title":["Mucormycosis in Iran: a systematic review"],"prefix":"10.1111","volume":"59","author":[{"given":"Afsane","family":"Vaezi","sequence":"first","affiliation":[{"name":"Student Research Committee Mazandaran University of Medical Sciences Sari Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Moazeni","sequence":"additional","affiliation":[{"name":"Department of Medical Mycology and Parasitology\/Invasive Fungi Research Center (IFRC) School of Medicine Mazandaran University of Medical Sciences Sari Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Taghi","family":"Rahimi","sequence":"additional","affiliation":[{"name":"Toxoplasmosis Research Center Mazandaran University of Medical Sciences Sari Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sybren","family":"de Hoog","sequence":"additional","affiliation":[{"name":"CBS\u2010KNAW Fungal Biodiversity Centre Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid","family":"Badali","sequence":"additional","affiliation":[{"name":"Department of Medical Mycology and Parasitology\/Invasive Fungi Research Center (IFRC) School of Medicine Mazandaran University of Medical Sciences Sari Iran"},{"name":"Molecular and Cell Biology Research Center (MCBRC) Mazandaran University of Medical Sciences Sari Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,2,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1470-9465.2004.00843.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.13.2.236"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/64.4.544"},{"key":"e_1_2_7_5_1","first-page":"799","article-title":"Identification and susceptibility of Rhizomucor spp. isolated from patients with cutaneous zygomycosis in China","volume":"49","author":"Wang SB","year":"2011","journal-title":"Med Mycol"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2001.tb00083.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(99)00142-6"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.70.8.634"},{"key":"e_1_2_7_9_1","first-page":"E792","article-title":"Rhinoorbitocerebral mucormycosis: a case report and literature review","volume":"13","author":"Martin\u2010Moro JG","year":"2008","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/jinf.2001.0831"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0037-86822011000200027"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11908-012-0272-6"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1086\/432579"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12081"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12281-013-0152-z"},{"key":"e_1_2_7_16_1","first-page":"231","article-title":"Rhino\u2010orbito\u2010cerebral mucormycosis. 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