{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T19:00:35Z","timestamp":1776970835737,"version":"3.51.4"},"reference-count":13,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,2,9]],"date-time":"2016-02-09T00:00:00Z","timestamp":1454976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007660","name":"University of Antwerp","doi-asserted-by":"crossref","award":["IOF-SBO 23900"],"award-info":[{"award-number":["IOF-SBO 23900"]}],"id":[{"id":"10.13039\/501100007660","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100007660","name":"University of Antwerp","doi-asserted-by":"crossref","award":["BOF-NOI 23214"],"award-info":[{"award-number":["BOF-NOI 23214"]}],"id":[{"id":"10.13039\/501100007660","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Oystershell Laboratories"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Many topical commercial products are currently available for the treatment of onychomycosis. However, limited data are available concerning their antifungal activity. Using an <jats:italic>in vitro<\/jats:italic> onychomycosis model, the daily application of seven nail formulations was compared to the antifungal reference drug amorolfine (Loceryl<jats:sup>\u00ae<\/jats:sup>) and evaluated for inhibitory activity against <jats:italic>Trichophyton mentagrophytes<\/jats:italic> using an agar diffusion test. Of all commercial nail formulations, only Excilor<jats:sup>\u00ae<\/jats:sup> and Nailner<jats:sup>\u00ae<\/jats:sup> demonstrated inhibitory activity, which was much lower compared to the daily application of Loceryl<jats:sup>\u00ae<\/jats:sup>. However, Excilor<jats:sup>\u00ae<\/jats:sup> showed similar efficacy compared to the conventional weekly application of Loceryl<jats:sup>\u00ae<\/jats:sup>. These results suggest a role for organic acids in the antifungal effect of Excilor<jats:sup>\u00ae<\/jats:sup> (acetic acid, ethyl lactate) and Nailner<jats:sup>\u00ae<\/jats:sup> (lactic acid, citric acid, ethyl lactate) as all tested formulations without organic acids were inactive.<\/jats:p>","DOI":"10.1111\/myc.12475","type":"journal-article","created":{"date-parts":[[2016,2,9]],"date-time":"2016-02-09T09:05:35Z","timestamp":1455008735000},"page":"327-330","source":"Crossref","is-referenced-by-count":12,"title":["Evaluation of topical antifungal products in an <i>in vitro<\/i> onychomycosis model"],"prefix":"10.1111","volume":"59","author":[{"given":"Reindert","family":"Sleven","sequence":"first","affiliation":[{"name":"Laboratory of Microbiology, Parasitology and Hygiene (LMPH) Faculty of Pharmaceutical, Biomedical and Veterinary Sciences University of Antwerp Antwerp Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen","family":"Lanckacker","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology, Parasitology and Hygiene (LMPH) Faculty of Pharmaceutical, Biomedical and Veterinary Sciences University of Antwerp Antwerp Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Delputte","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology, Parasitology and Hygiene (LMPH) Faculty of Pharmaceutical, Biomedical and Veterinary Sciences University of Antwerp Antwerp Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis","family":"Maes","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology, Parasitology and Hygiene (LMPH) Faculty of Pharmaceutical, Biomedical and Veterinary Sciences University of Antwerp Antwerp Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Cos","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology, Parasitology and Hygiene (LMPH) Faculty of Pharmaceutical, Biomedical and Veterinary Sciences University of Antwerp Antwerp Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.11.3.415"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/0255-0857.40522"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12323"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.10.013"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2012.02215.x"},{"key":"e_1_2_7_7_1","first-page":"15","article-title":"In vitro antimycotic activity and biological assay of nail permeation of a new climbazole\/octopirox hydrolacquer","volume":"1","author":"Frangi A","year":"2005","journal-title":"J Plast Dermatol"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mimet.2015.03.009"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00284-014-0585-9"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijfoodmicro.2004.05.020"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.4315\/0362-028X-65.8.1309"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/00362178085380301"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12211"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/00362178085380491"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fmyc.12475","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.12475","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T09:55:19Z","timestamp":1696499719000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/myc.12475"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,9]]},"references-count":13,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.1111\/myc.12475"],"URL":"https:\/\/doi.org\/10.1111\/myc.12475","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,9]]}}}