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Despite the lack of phase <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> data in first\u2010line treatment of invasive aspergillosis, increasing evidence supports the use of first\u2010line therapy. Here, we analyse the evidence of therapeutic activity, represented by favourable response rates, of caspofungin for invasive aspergillosis. A systematic literature search was conducted to identify international presentations and papers reporting monotherapy with caspofungin. Efficacy data are summarised separately for first\u2010line and salvage therapy. Thirty\u2010one papers and published abstracts reported caspofungin therapy for aspergillosis. Fifteen full papers and two abstracts fulfilled the criteria of reporting significant outcome data for caspofungin monotherapy for invasive aspergillosis. Consistent with other analyses and the known safety profile, few adverse events and associated terminations of caspofungin medication have been reported. Although a randomised, comparative, prospective study using caspofungin in this indication is still lacking, growing evidence supports the efficacy of this echinocandin not only for salvage but also for first\u2010line therapy.<\/jats:p>","DOI":"10.1111\/myc.12477","type":"journal-article","created":{"date-parts":[[2016,6,22]],"date-time":"2016-06-22T08:57:01Z","timestamp":1466585821000},"page":"480-493","source":"Crossref","is-referenced-by-count":25,"title":["Clinical evidence for caspofungin monotherapy in the first\u2010line and salvage therapy of invasive <i><scp>A<\/scp>spergillus<\/i> infections"],"prefix":"10.1111","volume":"59","author":[{"given":"Werner J.","family":"Heinz","sequence":"first","affiliation":[{"name":"Medizinische Klinik and Poliklinik II Infectious Diseases University of W\u00fcrzburg Medical Center W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"Buchheidt","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Mannheim University Hospital University of Heidelberg Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Ullmann","sequence":"additional","affiliation":[{"name":"Medizinische Klinik and Poliklinik II Infectious Diseases University of W\u00fcrzburg Medical Center W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,6,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/171.6.1545"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199203263261301"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10610"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/10408410903241444"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2012.08.003"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks266"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12081"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12060"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11908-010-0132-1"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/13693780802227159"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/13693786.2010.535030"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200906-050AL"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2010.01885.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir485"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2009.11.005"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-13-29"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/12.6.1147"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1086\/595846"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2011.044636"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-011-1397-5"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2010.01903.x"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp080325"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3062.2002.t01-2-02002.x"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1507.090043"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc061720"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq279"},{"key":"e_1_2_9_28_1","first-page":"46","article-title":"Invasive pulmonary aspergillosis due to a multi\u2010azole resistant Aspergillus fumigatus","volume":"67","author":"Jeurissen A","year":"2012","journal-title":"Acta Clin Belg"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2009.09.002"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1086\/525258"},{"key":"e_1_2_9_31_1","unstructured":"HerbrechtR.Update of ECIL guidelines for antifungal therapy in leukemia and HSCT patients 2013. 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