{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T10:29:25Z","timestamp":1784543365808,"version":"3.55.0"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,2,11]],"date-time":"2016-02-11T00:00:00Z","timestamp":1455148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Epidemiological cut\u2010off values (ECVs) based on minimal inhibitory concentration (MIC) distribution have been recently proposed for some antifungal drug\/<jats:italic>Cryptococcus neoformans<\/jats:italic> combinations. However, these ECVs vary according to the species studied, being serotypes and the geographical origin of strains, variables to be considered. The aims were to define the wild\u2010type (WT) population of the <jats:italic>C. neoformans<\/jats:italic> species complex (<jats:italic>C. neoformans<\/jats:italic>) isolated from patients living in Argentina, and to propose ECVs for six antifungal drugs. A total of 707 unique <jats:italic>C. neoformans<\/jats:italic> isolates obtained from HIV patients suffering cryptococcal meningitis were studied. The <jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content> of amphotericin B, flucytosine, fluconazole, itraconazole, voriconazole and posaconazole was determined according to the EDef 7.2 (EUCAST) reference document. The MIC distribution, MIC<jats:sub>50<\/jats:sub>, MIC<jats:sub>90<\/jats:sub> and ECV for each of these drugs were calculated. The highest ECV, which included \u226595% of the WT population modelled, was observed for flucytosine and fluconazole (32 \u03bcg ml<jats:sup>\u22121<\/jats:sup> each). For amphotericin B, itraconazole, voriconazole and posaconazole, the ECVs were: 0.5, 0.5, 0.5 and 0.06 \u03bcg ml<jats:sup>\u22121<\/jats:sup> respectively. The ECVs determined in this study may aid in identifying the <jats:italic>C. neoformans<\/jats:italic> strains circulating in Argentina with decreased susceptibility to the antifungal drugs tested.<\/jats:p>","DOI":"10.1111\/myc.12479","type":"journal-article","created":{"date-parts":[[2016,2,11]],"date-time":"2016-02-11T13:10:35Z","timestamp":1455196235000},"page":"351-356","source":"Crossref","is-referenced-by-count":16,"title":["Susceptibility profile and epidemiological cut\u2010off values of <i>Cryptococcus neoformans<\/i> species complex from Argentina"],"prefix":"10.1111","volume":"59","author":[{"given":"Susana","family":"C\u00f3rdoba","sequence":"first","affiliation":[{"name":"Instituto Nacional de Enfermedades Infecciosas \u201cDr. C. G. Malbr\u00e1n\u201d Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria G.","family":"Isla","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Enfermedades Infecciosas \u201cDr. C. G. Malbr\u00e1n\u201d Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanda","family":"Szusz","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Enfermedades Infecciosas \u201cDr. C. G. Malbr\u00e1n\u201d Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Vivot","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Enfermedades Infecciosas \u201cDr. C. G. Malbr\u00e1n\u201d Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Altamirano","sequence":"additional","affiliation":[{"name":"C\u00e1tedra de C\u00e1lculo Estad\u00edstico y Biometr\u00eda Facultad de Ciencias Agrarias y Forestales Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graciela","family":"Davel","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Enfermedades Infecciosas \u201cDr. C. G. Malbr\u00e1n\u201d Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,2,11]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"28","article-title":"Situaci\u00f3n de las micosis en la Rep\u00fablica Argentina","volume":"39","author":"Davel G","year":"2007","journal-title":"Rev Argent Microbiol"},{"key":"e_1_2_6_3_1","first-page":"332","volume-title":"SIDA y enfermedades asociadas. Diagn\u00f3stico, cl\u00ednica y tratamiento","author":"Negroni R","year":"2008"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/649858"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01271-10"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01115-12"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.06252-11"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00048-11"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2011.07.007"},{"key":"e_1_2_6_10_1","unstructured":"Clinical and Laboratory Standards Institute.Reference method for broth dilution antifungal susceptibility testing of yeasts. Approved standard. Third Edition. CLSI document M27\u2010A3. 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Method for the determination of broth dilution minimum Inhibitory concentrations of antifungal agents for yeasts.2012.www.eucast.org[accessed on 11 April 2012].","DOI":"10.1111\/j.1469-0691.2012.03880.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2006.01377.x"},{"key":"e_1_2_6_13_1","volume-title":"The Yeast, a Taxonomic Study","author":"Kurtzman CP","year":"2011"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01631-10"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-015-9871-8"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00216-13"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.6.1544-1548.2000"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fmyc.12479","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.12479","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T05:13:45Z","timestamp":1696482825000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/myc.12479"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,11]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1111\/myc.12479"],"URL":"https:\/\/doi.org\/10.1111\/myc.12479","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,11]]}}}